Cancer Cell Membrane-Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy
文献类型：期刊论文
| 作者 | Ze Chen; Pengfei Zhao; Zhenyu Luo; Mingbin Zheng; Hao Tian; Ping Gong; Guanhui Gao; Hong Pan; Lanlan Liu; Aiqing Ma |
| 刊名 | ACS Nano
 |
| 出版日期 | 2016 |
| 英文摘要 | An active cell membrane−camouflaged nanoparticle, owning to membrane antigens and membrane structure, can achieve special properties such as specific recognition, long blood circulation, and immune escaping. Herein, we reported a cancer cell membrane−cloaked nanoparticle system as a theranostic nanoplatform. The biomimetic nanoparticles (indocyanine green (ICG)-loaded and cancer cell membrane-coated nanoparticles, ICNPs) exhibit a core−shell nanostructure consisting of an ICGpolymeric core and cancer cell membrane shell. ICNPs demonstrated specific homologous targeting to cancer cells with good monodispersity, preferable photothermal response, and excellent fluorescence/photoacoustic (FL/PA) imaging properties. Benefited from the functionalization of the homologous binding adhesion molecules from cancer cell membranes, ICNPs significantly promoted cell endocytosis and homologous-targeting tumor accumulation in vivo. Moreover, ICNPs were also good at disguising as cells to decrease interception by the liver and kidney. Through nearinfrared (NIR)-FL/PA dual-modal imaging, ICNPs could realize real-time monitored in vivo dynamic distribution with high spatial resolution and deep penetration. Under NIR laser irradiation, ICNPs exhibited highly efficient photothermal therapy to eradicate xenografted tumor. The robust ICNPs with homologous properties of cancer cell membranes can serve as a bionic nanoplatform for cancer-targeted imaging and phototherapy. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.acs.org/doi/pdf/10.1021/acsnano.6b04695 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10697]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ACS Nano |
| 推荐引用方式 GB/T 7714 | Ze Chen,Pengfei Zhao,Zhenyu Luo,et al. Cancer Cell Membrane-Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy[J]. ACS Nano,2016. |
| APA | Ze Chen.,Pengfei Zhao.,Zhenyu Luo.,Mingbin Zheng.,Hao Tian.,...&Lintao Cai.(2016).Cancer Cell Membrane-Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy.ACS Nano. |
| MLA | Ze Chen,et al."Cancer Cell Membrane-Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy".ACS Nano (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。