Metabolizable Small Gold Nanorods: Size-dependent Cytotoxicity Cell Uptake and In Vivo Biodistribution
文献类型：期刊论文
| 作者 | Li, Zhibin; Tang, Siying; Wang, Beike; Li, Yong; Huang, Hao; Wang, Huaiyu; Li, Penghui; Li, Chengzhang; Chu, Paul K.; Yu, Xue-Feng |
| 刊名 | ACS BIOMATERIALS-SCIENCE & ENGINEERING
 |
| 出版日期 | 2016 |
| 英文摘要 | Gold nanorods (AuNRs) with unique plasmonic properties in the near-infrared region have promising biomedical applications but suffer from poor in vivo clearance because of the large size. In this study, small AuNRs with a diameter of 7 nm (designated as sAuNRs) are found to have low toxicity and high clearance rates in vivo. Compared to common AuNRs with a diameter of 14 nm (designated as bAuNRs), sAuNRs exhibit similar surface plasmon resonance bands and photothermal efficiency as bAuNRs but have lower cytotoxicity as well as higher cell uptake. The in vivo biodistribution study indicates that only 0.68% of the intravenously injected sAuNRs remain in the body after 30 days, but the residual amount in the body after injection of bAuNRs is as high as 12.3%. The results demonstrate that the smaller AuNRs having lower toxicity and increased clearance in vivo have large clinical potential. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.5b00538 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10700]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ACS BIOMATERIALS-SCIENCE & ENGINEERING |
| 推荐引用方式 GB/T 7714 | Li, Zhibin,Tang, Siying,Wang, Beike,et al. Metabolizable Small Gold Nanorods: Size-dependent Cytotoxicity Cell Uptake and In Vivo Biodistribution[J]. ACS BIOMATERIALS-SCIENCE & ENGINEERING,2016. |
| APA | Li, Zhibin.,Tang, Siying.,Wang, Beike.,Li, Yong.,Huang, Hao.,...&Yu, Xue-Feng.(2016).Metabolizable Small Gold Nanorods: Size-dependent Cytotoxicity Cell Uptake and In Vivo Biodistribution.ACS BIOMATERIALS-SCIENCE & ENGINEERING. |
| MLA | Li, Zhibin,et al."Metabolizable Small Gold Nanorods: Size-dependent Cytotoxicity Cell Uptake and In Vivo Biodistribution".ACS BIOMATERIALS-SCIENCE & ENGINEERING (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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