Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy
文献类型：期刊论文
| 作者 | Jundong Shao; Hanhan Xie; Hao Huang; Zhibin Li; Zhengbo Sun; Yanhua Xu; Quanlan Xiao; Xue-Feng Yu; Yuetao Zhao; Han Zhang |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2016 |
| 英文摘要 | Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns such as the biodegradability as well as long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed by an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates the interior BPQDs from oxygen and water to enhance the photothermal stability, but also control the degradation rate of the BPQDs. The in vitro and in vivo experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good biocompatibility, and possess excellent PTT efficiency and tumour targeting ability as evidenced by highly efficient tumour ablation under near infrared (NIR) laser illumination. These BP-based nanospheres uniquely combine biodegradability and biocompatibility with high PTT efficiency, thus promising high clinical potential. |
| 收录类别 | SCI |
| 原文出处 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056460/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10712]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | NATURE COMMUNICATIONS |
| 推荐引用方式 GB/T 7714 | Jundong Shao,Hanhan Xie,Hao Huang,et al. Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy[J]. NATURE COMMUNICATIONS,2016. |
| APA | Jundong Shao.,Hanhan Xie.,Hao Huang.,Zhibin Li.,Zhengbo Sun.,...&Paul K. Chu.(2016).Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy.NATURE COMMUNICATIONS. |
| MLA | Jundong Shao,et al."Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy".NATURE COMMUNICATIONS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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