Synthesis of Amphiphilic Poly(β-aminoester) for Efficiently Minicircle DNA Delivery in Vivo
文献类型：期刊论文
| 作者 | J.Zhao; P.Huang; Z.Wang; Y.Tan; X.Hou; L.Zhang; C.Y.He; Z.Y.Chen |
| 刊名 | ACS applied materials & interfaces
 |
| 出版日期 | 2016 |
| 英文摘要 | Minicircle DNA (mcDNA) is a kind of enhanced nonviral DNA vector with excellent profiles in biosafety and transgene expression. Herein, we reported a novel amphiphilic polymer comprising polyethylenimine(PEI) modified Poly(β-amino ester) PEI–PBAE(C16) for efficient mcDNA delivery in vivo. The synthesized polymer could condense mcDNA into nanoscaled structure and exhibited efficient gene transfection ability without detectable cytotoxicity. Importantly, when injected into mouse intraperitoneally, these PEI–PBAE(C16) nanocomplexes were able to result in high level of trangene expression which lasted at least 72 h. Overall, these results demonstrated the PEI–PBAE(C16) can mediate effective and safe gene delivery in vivo with clinical application potential. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.acs.org/doi/full/10.1021/acsami.6b04412 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10719]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ACS applied materials & interfaces |
| 推荐引用方式 GB/T 7714 | J.Zhao,P.Huang,Z.Wang,et al. Synthesis of Amphiphilic Poly(β-aminoester) for Efficiently Minicircle DNA Delivery in Vivo[J]. ACS applied materials & interfaces,2016. |
| APA | J.Zhao.,P.Huang.,Z.Wang.,Y.Tan.,X.Hou.,...&Z.Y.Chen.(2016).Synthesis of Amphiphilic Poly(β-aminoester) for Efficiently Minicircle DNA Delivery in Vivo.ACS applied materials & interfaces. |
| MLA | J.Zhao,et al."Synthesis of Amphiphilic Poly(β-aminoester) for Efficiently Minicircle DNA Delivery in Vivo".ACS applied materials & interfaces (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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