c-Rel is Required for the Induction of pTregs in the Eye but Not in the Gut Mucosa
文献类型：期刊论文
| 作者 | Ting Wang; Weiyun Shi; Tingting Fan; Xiaochun Wan; Youhai H.Chen; Qingguo Ruan |
| 刊名 | IMMUNOLOGICAL INVESTIGATIONS
 |
| 出版日期 | 2016 |
| 英文摘要 | Regulatory T (Treg) cells play an integral role in maintaining immune homeostasis and preventing autoimmune diseases. Forkhead box P3 expression marks the commitment of progenit or cells to the Treg lineage. Although the essential function of the nuclear factor (NF)-κB family transcription factor c-Rel in the regulation of natural Treg cells has been firmly established, little is known about whether c-Rel is involved in the in vivo generation of peripheral Treg cells (pTregs),which develop from mature CD4+ conventional T cells outside of the thymus. We sought to answer this question through the induction of pTregs in the eye and gut mucosa using ovalbumin-specific T cell receptor transgenic mice that do or do not express c-Rel. Our results showed that Tregs can be induced in the eye in a c-Rel-dependent manner when immune-mediated inflammation occurs. However,c-Rel is dispensable for the induction of pTregs in the gut mucosa after oral antigen administration. Thus, c-Rel may play distinct roles in regulating the development of pTregs in different organs. |
| 收录类别 | SCI |
| 原文出处 | http://www.tandfonline.com/doi/abs/10.3109/08820139.2016.1172639 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10724]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | IMMUNOLOGICAL INVESTIGATIONS |
| 推荐引用方式 GB/T 7714 | Ting Wang,Weiyun Shi,Tingting Fan,et al. c-Rel is Required for the Induction of pTregs in the Eye but Not in the Gut Mucosa[J]. IMMUNOLOGICAL INVESTIGATIONS,2016. |
| APA | Ting Wang,Weiyun Shi,Tingting Fan,Xiaochun Wan,Youhai H.Chen,&Qingguo Ruan.(2016).c-Rel is Required for the Induction of pTregs in the Eye but Not in the Gut Mucosa.IMMUNOLOGICAL INVESTIGATIONS. |
| MLA | Ting Wang,et al."c-Rel is Required for the Induction of pTregs in the Eye but Not in the Gut Mucosa".IMMUNOLOGICAL INVESTIGATIONS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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