CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet
文献类型：期刊论文
| 作者 | Huang, Chen; Wang, Miaomiao; Ren, Lirong; Xiang, Liang; Chen, Jie; Li, Mengxia; Xiao, Tianxia; Ren, Peigen; Xiong, Likuan; Zhang, Jian V. |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2016 |
| 英文摘要 | Obesity has become a global epidemic disease, contributing to increases in the prevalence of type 2 diabetes. CMKLR1, one of the receptors for chemerin, has a wide range of functions in physiological and pathological activity, including innate and adaptive immunity, inflammation, metabolism and reproduction. Inour study, CMKLR1 deficiency did not influence the gain of body weight but did exacerbate glucoseintolerance, increase serum insulin level, and promote insulin resistance in mice on high fat diets. The expression of thermogenesis related genes was examined and indicated to decrease in CMKLR1 knockout (KO) mice in both normal and cold environments, which indicated CMKLR1 influence the thermogenesisprocess. Cold exposure induced significant body mass decrease and improved glucose tolerance and insulin resistance in wild type HFD mice but had no obvious effect on CMKLR1 1(0 HFD mice. In vitro, loss of CMKLR1 did not significantly influence the differentiation of stromal vascular fibroblasts (SVFs) derived from adipose tissue, but did suppress the expression of thermogenesis related genes. Collectively, these data demonstrate that CMKLR1 deficiency induces inbalance of glucose metabolism and impairs the cold induced-thermogenesis process in high diet models. |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/jor.23079/full |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10735]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
| 推荐引用方式 GB/T 7714 | Huang, Chen,Wang, Miaomiao,Ren, Lirong,et al. CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016. |
| APA | Huang, Chen.,Wang, Miaomiao.,Ren, Lirong.,Xiang, Liang.,Chen, Jie.,...&Zhang, Jian V..(2016).CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. |
| MLA | Huang, Chen,et al."CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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