Fecal bacterial microbiome diversity in chronic HIV-infected patients in China
文献类型：期刊论文
| 作者 | Sun, Yang; Ma, Yingfei; Lin, Ping; Tang, Yi-Wei; Yang, Liying; Shen, Yinzhong; Zhang, Renfan; Liu, Li; Cheng, Jun; Shao, Jiashen |
| 刊名 | EMERGING MICROBES & INFECTIONS
 |
| 出版日期 | 2016 |
| 英文摘要 | The purpose of this study was to identify fecal bacterial microbiome changes in patients with chronic human immunodeficiency virus (HIV) infection in China. Bacterial 16S rRNA genes were amplified, sequenced (454 pyrosequencing), and clustered into operational taxonomic units using the QIIME software. Relative abundance at the phylum and genus levels were calculated. Alpha diversity was determined by Chao 1 and observed-species indices, and beta diversity was determined by double principal component analysis using the estimated phylogeny-based unweighted Unifrac distance matrices. Fecal samples of the patients withchronic HIV-infection tended to be enriched with bacteria of the phyla Firmicutes (47.20%+/- 0.43 relative abundance) and Proteobacteria (37.21%+/- 0.36) compared with those of the non-HIV infected controls (17.95%+/- 0.06 and 3.81%+/- 0.02, respectively). Members of the genus Bilophila were exclusively detected in samples of the non-HIV infected controls. Bacteroides and arabacteroides were more abundantin the chronic HIV-infected patients. Our study indicated that chronic HIV-infected patients in China have afecal bacterial microbiome composition that is largely different from that found in non-HIV infected controls, and further study is needed to evaluate whether microbiome changes play a role in disease complications inthe distal gut, including opportunistic infections. |
| 收录类别 | SCI |
| 原文出处 | http://www.nature.com/emi/journal/v5/n4/abs/emi201625a.html |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10744]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | EMERGING MICROBES & INFECTIONS |
| 推荐引用方式 GB/T 7714 | Sun, Yang,Ma, Yingfei,Lin, Ping,et al. Fecal bacterial microbiome diversity in chronic HIV-infected patients in China[J]. EMERGING MICROBES & INFECTIONS,2016. |
| APA | Sun, Yang.,Ma, Yingfei.,Lin, Ping.,Tang, Yi-Wei.,Yang, Liying.,...&Lu, Hongzhou.(2016).Fecal bacterial microbiome diversity in chronic HIV-infected patients in China.EMERGING MICROBES & INFECTIONS. |
| MLA | Sun, Yang,et al."Fecal bacterial microbiome diversity in chronic HIV-infected patients in China".EMERGING MICROBES & INFECTIONS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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