Conventional kinesin KIF5B mediates adiponectin secretion in 3T3-L1 adipocytes
文献类型：期刊论文
| 作者 | Cui, Ju; Pang, Jing; Lin, Ya-Jun; Jiang, Ping; Gong, Huan; Wang, Zai; Li, Jian; Cai, Jian-Ping; Huang, Jian-Doug; Zhang, Tie-Mei |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2016 |
| 英文摘要 | Insulin stimulates adiponectin secretion and glucose transporter type 4 (GLUT4) translocation in adipocyte to regulate metabolism homeostasis. Similar to GLUT4 translocation, intracellular trafficking and release of adiponectin in adipocytes relies on the trans-Golgi network and endosomal system. Recent studies show that the heavy chain of conventional kinesin (KIF5B) mediates GLUT4 translocation in murine 3T3-L1 adipocytes, however, the motor machinery involved in mediating intracellular trafficking and release of adiponectin is unknown. Here, we examined the role of KIF5B in the regulation of adiponectin secretion. The KIF5B level was up-regulated during 3T3-L1 adipogenesis. This increase in cytosolic KIF5B was synchronized with the induction of adiponectin. Endogenous KIF5B and adiponectin were partially colocalized at the peri-nuclear and cytosolic regions. In addition, adiponectin-containing vesicles were co-immunoprecipitated with KIF5B. Knockdown of KIF5B resulted in a marked inhibition of adiponectin secretion and overexpression of KIF5B enhanced adiponectin release, whereas leptin secretion was not affected by changes in KIF5B expression. These data suggest that the secretion of adiponectin, but not leptin, is dependent on functional KIF5B. (C) 2016 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0006291X16309263 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10745]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
| 推荐引用方式 GB/T 7714 | Cui, Ju,Pang, Jing,Lin, Ya-Jun,et al. Conventional kinesin KIF5B mediates adiponectin secretion in 3T3-L1 adipocytes[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016. |
| APA | Cui, Ju.,Pang, Jing.,Lin, Ya-Jun.,Jiang, Ping.,Gong, Huan.,...&Zhang, Tie-Mei.(2016).Conventional kinesin KIF5B mediates adiponectin secretion in 3T3-L1 adipocytes.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. |
| MLA | Cui, Ju,et al."Conventional kinesin KIF5B mediates adiponectin secretion in 3T3-L1 adipocytes".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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