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In-plane microvortices micromixer-based AC electrothermal for testing drug induced death of tumor cells
文献类型：期刊论文
| 作者 | Qi Lang; Yukun Ren; Divia Hobson; Ye Tao; Likai Hou; Yankai Jia; Qingming Hu; Jiangwei Liu; Xin Zhao; Hongyuan Jiang |
| 刊名 | Biomicrofluidics
 |
| 出版日期 | 2016 |
| 英文摘要 | Herein, we first describe a perfusion chip integrated with an AC electrothermal (ACET) micromixer to supply a uniform drug concentration to tumor cells. The inplane fluid microvortices for mixing were generated by six pairs of reconstructed novel ACET asymmetric electrodes. To enhance the mixing efficiency, the novel ACET electrodes with rotating angles of 0 , 30 , and 60 were investigated. The asymmetric electrodes with a rotating angle of 60 exhibited the highest mixing efficiency by both simulated and experimental results. The length of the mixing area is 7 mm, and the mixing efficiency is 89.12% (approximate complete mixing) at a voltage of 3V and a frequency of 500 kHz. The applicability of our micromixer with electrodes rotating at 60 was demonstrated by the drug (tamoxifen) test of human breast cancer cells (MCF-7) for five days, which implies that our ACET inplane microvortices micromixer has great potential for the application of drug induced rapid death of tumor cells and mixing of biomaterials in organs-on-a-chip systems. Published by AIP Publishing |
| 收录类别 | SCI |
| 原文出处 | http://scitation.aip.org/content/aip/journal/bmf/10/6/10.1063/1.4967455 |
| 语种 | 英语 |
| WOS记录号 | WOS:000390113600003 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10750]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Biomicrofluidics |
| 推荐引用方式 GB/T 7714 | Qi Lang,Yukun Ren,Divia Hobson,et al. In-plane microvortices micromixer-based AC electrothermal for testing drug induced death of tumor cells[J]. Biomicrofluidics,2016. |
| APA | Qi Lang.,Yukun Ren.,Divia Hobson.,Ye Tao.,Likai Hou.,...&Hongyuan Jiang.(2016).In-plane microvortices micromixer-based AC electrothermal for testing drug induced death of tumor cells.Biomicrofluidics. |
| MLA | Qi Lang,et al."In-plane microvortices micromixer-based AC electrothermal for testing drug induced death of tumor cells".Biomicrofluidics (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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