A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile.
文献类型：期刊论文
| 作者 | Zhang, Bao-Zhong; Cai, Jianpiao; Yu, Bin; Hua, Yanhong; Lau, Candy Choiyi; Kao, Richard Yi-Tsun Tsun; Sze, Kong-Hung; Yuen, Kwok-Yung; Huang, Jian-Dong |
| 刊名 | BMC INFECTIOUS DISEASES
 |
| 出版日期 | 2016 |
| 英文摘要 | Background: Clostridium difficile-associated disease (CDAD) constitutes a great majority of hospital diarrhea cases in industrialized countries and is induced by two types of large toxin molecules: toxin A (TcdA) and toxin B (TcdB). Development of immunotherapeutic approaches, either active or passive, has seen a resurgence in recent years. Studies have described vaccine plasmids that express either TcdA and/or TcdB receptor binding domain (RBD). However, the effectiveness of one vector encoding both toxin RBDs against CDAD has not been evaluated. |
| 收录类别 | SCI |
| 原文出处 | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1924-1 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10753]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BMC INFECTIOUS DISEASES |
| 推荐引用方式 GB/T 7714 | Zhang, Bao-Zhong,Cai, Jianpiao,Yu, Bin,et al. A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile.[J]. BMC INFECTIOUS DISEASES,2016. |
| APA | Zhang, Bao-Zhong.,Cai, Jianpiao.,Yu, Bin.,Hua, Yanhong.,Lau, Candy Choiyi.,...&Huang, Jian-Dong.(2016).A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile..BMC INFECTIOUS DISEASES. |
| MLA | Zhang, Bao-Zhong,et al."A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile.".BMC INFECTIOUS DISEASES (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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