Cartilage Degeneration and Excessive Subchondral Bone Formation in Spontaneous Osteoarthritis Involves Altered TGF-beta Signaling
文献类型：期刊论文
| 作者 | Zhao, Weiwei; Wang, Ting; Luo, Qiang; Chen, Yan; Leung, Victor Y. L.; Wen, Chunyi; Shah, Mohammed F.; Pan, Haobo; Chiu, KwongYuen; Cao, Xu |
| 刊名 | JOURNAL OF ORTHOPAEDIC RESEARCH
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| 出版日期 | 2016 |
| 英文摘要 | Transforming growth factor-b (TGF-b) has been demonstrated as a potential therapeutic target in osteoarthritis. However, beneficial effects of TGF-b supplement and inhibition have both been reported, suggesting characterization of the spatiotemporal distribution of TGF-b during the whole time course of osteoarthritis is important. To investigate the activity of TGF-b in osteoarthritis progression, we collected knee joints from Dunkin–Hartley (DH) guinea pigs at 3, 6, 9, and 12-month old (n¼8), which develop spontaneous osteoarthritis in a manner extraordinarily similar to humans. Via histology and micro-computed tomography (CT) analysis, we found that the joints exhibited gradual cartilage degeneration, subchondral plate sclerosis, and elevated bone remodeling during aging. The degenerating cartilage showed a progressive switch of the expression of phosphorylated Smad2/3 to Smad1/5/8, suggesting dual roles of TGF-b/Smad signaling during chondrocyte terminal differentiation in osteoarthritis progression. In subchondral bone, we found that the locations and age-related changes of osterix þ osteoprogenitors were in parallel with active TGF-b, which implied the excessive osteogenesis may link to the activity of TGF-b. Our study, therefore, suggests an association of cartilage degeneration and excessive bone remodeling with altered TGF-b signaling in osteoarthritis progression of DH guinea pigs. 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/jor.23079/full |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10759]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | JOURNAL OF ORTHOPAEDIC RESEARCH |
| 推荐引用方式 GB/T 7714 | Zhao, Weiwei,Wang, Ting,Luo, Qiang,et al. Cartilage Degeneration and Excessive Subchondral Bone Formation in Spontaneous Osteoarthritis Involves Altered TGF-beta Signaling[J]. JOURNAL OF ORTHOPAEDIC RESEARCH,2016. |
| APA | Zhao, Weiwei.,Wang, Ting.,Luo, Qiang.,Chen, Yan.,Leung, Victor Y. L..,...&Lu, William W..(2016).Cartilage Degeneration and Excessive Subchondral Bone Formation in Spontaneous Osteoarthritis Involves Altered TGF-beta Signaling.JOURNAL OF ORTHOPAEDIC RESEARCH. |
| MLA | Zhao, Weiwei,et al."Cartilage Degeneration and Excessive Subchondral Bone Formation in Spontaneous Osteoarthritis Involves Altered TGF-beta Signaling".JOURNAL OF ORTHOPAEDIC RESEARCH (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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