Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface
文献类型：期刊论文
| 作者 | Zhao, Ying; Wong, Hoi Man; Lui, So Ching; Chong, Eva Y. W.; Wu, Guosong; Zhao, Xiaoli; Wang, Chong; Pan, Haobo; Cheung, Kenneth M. C.; Wu, Shuilin |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2016 |
| 英文摘要 | This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer. |
| 收录类别 | SCI |
| 原文出处 | http://pubs.acs.org/doi/abs/10.1021/acsami.5b10881 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10766]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | ACS APPLIED MATERIALS & INTERFACES |
| 推荐引用方式 GB/T 7714 | Zhao, Ying,Wong, Hoi Man,Lui, So Ching,et al. Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface[J]. ACS APPLIED MATERIALS & INTERFACES,2016. |
| APA | Zhao, Ying.,Wong, Hoi Man.,Lui, So Ching.,Chong, Eva Y. W..,Wu, Guosong.,...&Yeung, Kelvin W. K..(2016).Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface.ACS APPLIED MATERIALS & INTERFACES. |
| MLA | Zhao, Ying,et al."Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface".ACS APPLIED MATERIALS & INTERFACES (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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