Effect of l-lysine-assisted surface grafting for nano-hydroxyapatite on mechanical properties and invitro bioactivity of poly(lactic acid-co-glycolic acid)
文献类型：期刊论文
| 作者 | Jiang Liuyun; Jiang Lixin; Xiong Chengdong; Xu Lijuan; Li Ye |
| 刊名 | JOURNAL OF BIOMATERIALS APPLICATIONS
 |
| 出版日期 | 2016 |
| 英文摘要 | It is promising and challenging to study surface modification for nano-hydroxyapatite to improve the dispersion and enhance the mechanical propertiesand bioactivity of poly(lactic acid-co-glycolic acid). In this paper, we designed an effective new surface grafting with the assist of l-lysine for nano-hydroxyapatite, and the nano-hydroxyapatite surface grafted with the assist of l-lysine (g-nano-hydroxyapatite) was incorporated into poly(lactic acid-co-glycolic acid) to develop a series of g-nano-hydroxyapatite/poly(lactic acid-co-glycolic acid) nano-composites. The surface modification reaction for nano-hydroxyapatite, the mechanical properties, and invitro human osteoblast-like cell (MG-63) response were characterized and investigated by Fourier transformation infrared, thermal gravimetric analysis, dispersion test, electromechanical universal tester, differential scanning calorimeter measurements, and invitro cells culture experiment. The results showed that the grafting amount on the surface of nano-hydroxyapatite was enhanced with the increaseof l-lysine, and the dispersion of nano-hydroxyapatite was improved more, so that it brought about better promotion crystallization and more excellentmechanical enhancement effect for poly(lactic acid-co-glycolic acid), comparing with the unmodified nano-hydroxyapatite. Moreover, the cells' attachment and proliferation results confirmed that the incorporation of the g-nano-hydroxyapatite into poly(lactic acid-co-glycolic acid) exhibited better biocompatibility than poly(lactic acid-co-glycolic acid). The above results indicated that the new surface grafting with the assist of l-lysine for nano-hydroxyapatite was an ideal novel surface modification method, which brought about better mechanical enhancement effect and invitro bioactivity forpoly(lactic acid-co-glycolic acid) with adding higher g-nano-hydroxyapatite content, suggesting it had a great potential to be used as bone fracture internal fixation materials in future. |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pubmed/25940015 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10768]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | JOURNAL OF BIOMATERIALS APPLICATIONS |
| 推荐引用方式 GB/T 7714 | Jiang Liuyun,Jiang Lixin,Xiong Chengdong,et al. Effect of l-lysine-assisted surface grafting for nano-hydroxyapatite on mechanical properties and invitro bioactivity of poly(lactic acid-co-glycolic acid)[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2016. |
| APA | Jiang Liuyun,Jiang Lixin,Xiong Chengdong,Xu Lijuan,&Li Ye.(2016).Effect of l-lysine-assisted surface grafting for nano-hydroxyapatite on mechanical properties and invitro bioactivity of poly(lactic acid-co-glycolic acid).JOURNAL OF BIOMATERIALS APPLICATIONS. |
| MLA | Jiang Liuyun,et al."Effect of l-lysine-assisted surface grafting for nano-hydroxyapatite on mechanical properties and invitro bioactivity of poly(lactic acid-co-glycolic acid)".JOURNAL OF BIOMATERIALS APPLICATIONS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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