miR-9-5p miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation Differentiation and Adhesion
文献类型：期刊论文
| 作者 | Sun, Tianhao; Leung, Frankie; Lu, William W. |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2016 |
| 英文摘要 | This study was designed to evaluate the effects of strontium on the expression levels of microRNAs (miRNAs) and to explore their effects on skeletal cell proliferation, differentiation, adhesion, and apoptosis.The targets of these miRNAs were also studied. Molecular cloning, cell proliferation assay, cell apoptosis assay, quantitative real-time PCR, and luciferase reporter assay were used. Strontium altered theexpression levels of miRNAs in vitro and in vivo. miR-9-5p, miR-675-5p, and miR-138-5p impaired skeletalcell proliferation, cell differentiation and cell adhesion. miR-9-5p and miR-675-5p induced MC3T3-E1 cellapoptosis more specifically than miR-138-5p. miR-9-5p, miR-675-5p, and miR-138-5p targeted glycogen synthase kinase 3 (GSK3), ATPase Aminophospholipid Transporter Class I Type 8A Member 2 (ATP8A2), and Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1), respectively. Low-density lipoprotein receptor-related protein 5 (LRP5) played a positive role in skeletal development. miR-9-5p, miR-675-5p, and miR-138-5p damage strontium and LRP5-mediated skeletal cell proliferation, differentiation, andadhesion, and induce cell apoptosis by targeting GSK3, ATP8A2, and EIF4EBP1, respectively. |
| 收录类别 | SCI |
| 原文出处 | http://www.mdpi.com/1422-0067/17/2/236/htm |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10771]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| 推荐引用方式 GB/T 7714 | Sun, Tianhao,Leung, Frankie,Lu, William W.. miR-9-5p miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation Differentiation and Adhesion[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016. |
| APA | Sun, Tianhao,Leung, Frankie,&Lu, William W..(2016).miR-9-5p miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation Differentiation and Adhesion.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. |
| MLA | Sun, Tianhao,et al."miR-9-5p miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation Differentiation and Adhesion".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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