The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis
文献类型：期刊论文
| 作者 | Sun, Mengge; Zhou, Xiaoya; Chen, Lili; Huang, Shishu; Leung, Victor; Wu, Nan; Pan, Haobo; Zhen, Wanxin; Lu, William; Peng, Songlin |
| 刊名 | BIOMED RESEARCH INTERNATIONAL
 |
| 出版日期 | 2016 |
| 英文摘要 | MicroRNAs are involved in many cellular and molecular activities and played important roles in many biological and pathological processes, such as tissue formation, cancer development, diabetes, neurodegenerative diseases, and cardiovascular diseases. Recently, it has been reported that microRNAscan modulate the differentiation and activities of osteoblasts and osteoclasts, the key cells that are involvedin bone remodeling process. Meanwhile, the results from our and other research groups showed that theexpression profiles of microRNAs in the serum and bone tissues are significantly different inpostmenopausal women with or without fractures compared to the control. Therefore, it can be postulated that microRNAs might play important roles in bone remodeling and that they are very likely to be involved inthe pathological process of postmenopausal osteoporosis. In this review, we will present the updated research on the regulatory roles of microRNAs in osteoblasts and osteoclasts and the expression profiles ofmicroRNAs in osteoporosis and osteoporotic fracture patients. The perspective of serum microRNAs asnovel biomarkers in bone loss disorders such as osteoporosis has also been discussed. |
| 收录类别 | SCI |
| 原文出处 | http://www.hindawi.com/journals/bmri/2016/1652417/abs/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10773]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | BIOMED RESEARCH INTERNATIONAL |
| 推荐引用方式 GB/T 7714 | Sun, Mengge,Zhou, Xiaoya,Chen, Lili,et al. The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis[J]. BIOMED RESEARCH INTERNATIONAL,2016. |
| APA | Sun, Mengge.,Zhou, Xiaoya.,Chen, Lili.,Huang, Shishu.,Leung, Victor.,...&Peng, Songlin.(2016).The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis.BIOMED RESEARCH INTERNATIONAL. |
| MLA | Sun, Mengge,et al."The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis".BIOMED RESEARCH INTERNATIONAL (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。