Computational modeling of full-length prochemerin from human
文献类型：会议论文
| 作者 | Huang qingsheng; Xiao tianxia; Zhang jian V. |
| 出版日期 | 2012 |
| 会议名称 | IEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on Biomedical and Health Engineering |
| 会议地点 | Hong Kong |
| 英文摘要 | Chemerin is a protein bearing chemotaxis and anti-inflammation functions. Truncation of C-terminal region of chemerin precursor, prochemerin, regulates its activity. A reliable structure may help us understand the mechanism of such regulation. We model the full length prochemerin with a mixed strategy, that the cystatin-fold domain near the N-terminus is based on homology modeling of a template of cystatin, while the region near the C-terminus is built with ab initio modeling, involving docking, energy minimization, and molecular dynamics simulation. The resulted structure shows that the C-terminal region hinders residues Glu143 and Asp144from interacting other molecules. © 2012 IEEE.(29 refs) |
| 收录类别 | EI |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/4298]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2012 |
| 推荐引用方式 GB/T 7714 | Huang qingsheng,Xiao tianxia,Zhang jian V.. Computational modeling of full-length prochemerin from human[C]. 见:IEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on Biomedical and Health Engineering. Hong Kong. |
入库方式： OAI收割
来源：深圳先进技术研究院
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