Indocyanine Green Loaded Lipid-Polymer Nanoparticles for Cancer Imaging and Therapy
文献类型：会议论文
| 作者 | Mingbin Zheng; Pengfei Zhao; Cuifang Zheng; Zhenyu Luo; Ping Gong; Lintao Cai |
| 出版日期 | 2015 |
| 会议名称 | ChinaNanomedicine 2015 |
| 会议地点 | Hangzhou, China |
| 英文摘要 | Indocyanine green (ICG) is a FDA-approved near-infrared (NIR) dye and has been applied in optically mediated diagnostic and photothermal/photodynamic therapy. However, unstable properties in aqueous media and quick clearance from the body limit the application of the ICG. To overcome these limitation, we report the development of ICG loaded poly (lactic-co-glycolic acid) (PLGA)-lecithin-polyethylene glycol (PEG) nanoparticles (INPs) with 39nm, 68nm and 116nm. NIR imaging in vivo and photothermal therapy illustrated that 68nm INPs showed the strongest efficiency to suppress BxPC-3 xenograft tumor growth due to abundant accumulation in tumor by the passive-targeting of nanoparticles. Moreover, INPs with folic acid (FA) as targeting ligand (FA-INPs) were designed. FA-INPs showed excellent optical properties compared to the free ICG, exhibited highly selective localization to folate receptor over-expessing MCF-7 xenograft tumor and prolonged ICG circulation in vivo. We also fabricated doxorubicin (DOX) and ICG loaded PLGA-lecithin-PEG nanoparticles (DINPs). In comparison with chemo or photothermal therapy alone, the combined therapy of DINPs with laser irradiation synergistically induced the apoptosis and death of DOX-sensitive MCF-7 and DOX-resistant MCF-7/ADR cells, and suppressed MCF-7 and MCF-7/ADR tumor growth in vivo. Notably, no tumor recurrence was observed after only a single dose of DINPs with laser irradiation. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| WOS记录号 | WOS:000373923400212 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7434]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Mingbin Zheng,Pengfei Zhao,Cuifang Zheng,et al. Indocyanine Green Loaded Lipid-Polymer Nanoparticles for Cancer Imaging and Therapy[C]. 见:ChinaNanomedicine 2015. Hangzhou, China. |
入库方式： OAI收割
来源：深圳先进技术研究院
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