Remote and Noninvasive NIR-Triggered DOX Release from DOX/ICG-Loaded Temperature-Responsive Nanoparticles to Promote Anti-Tumor Effect
文献类型：会议论文
| 作者 | Mingbin Zheng; Pengfei Zhao; Zhenyu Luo; Ping Gong; Guanhui Gao; Zonghai Sheng; Cuifang Zheng; Chi Chen; Yifan Ma; Lintao Cai |
| 出版日期 | 2015 |
| 会议名称 | ChinaNanomedicine 2015 |
| 会议地点 | Hangzhou, China |
| 英文摘要 | Smart nanoparticles (NPs) that respond to external stimulations, including light, hyperthermia, reduction/oxidation and ultrasound have been developing to achieve optimal drug release in tumor tissues. However, applying these smart NPs to attain high antitumor performance is hampered by limited drug carriers and inefficient spatiotemporal control.[1] In this study, we report a noninvasive NIR-driven, temperature-sensitive nanoparticles (DI-NPs) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). This theranostic delivery system applies thermo-responsive lipid to controllably release the drug, utilizes the fluorescence (FL) of DOX and ICG to real-time trace the distribution of NPs, and employs DOX/ICG to treat cancer by chemo/photothermal therapy. DI-NPs exhibit uniform size distribution, excellent FL/size stability, enhanced response to temperature, and increased drug release through laser irradiation. DI-NPs also show long retention time, spatiotemporally-controlled release of DOX in tumor tissues, and enhanced ICG and DOX accumulation. The thermo-sensitive DI-NPs manifest a superior efficiency to promote apoptosis of tumor cells, and completely suppress tumor growth without side-effect. This study may provide a new generation of smart strategy for combinatorial cancer therapy. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| WOS记录号 | WOS:000373923400299 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7437]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Mingbin Zheng,Pengfei Zhao,Zhenyu Luo,et al. Remote and Noninvasive NIR-Triggered DOX Release from DOX/ICG-Loaded Temperature-Responsive Nanoparticles to Promote Anti-Tumor Effect[C]. 见:ChinaNanomedicine 2015. Hangzhou, China. |
入库方式： OAI收割
来源：深圳先进技术研究院
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