Smart Nanomedicine with Spatiotemporal Control for NIR-Triggered Drug Release abd Enhanced Synergistic Antitumor Therapy
文献类型：会议论文
| 作者 | Pengfei Zhao; Mingbin Zheng; Zhenyu Luo; Guanhui Gao; Cuifang Zheng; Ping Gong; Zonghai Sheng; Yifan Ma; Lintao Cai |
| 出版日期 | 2015 |
| 会议名称 | ChinaNanomedicine 2015 |
| 会议地点 | Hangzhou, China |
| 英文摘要 | Smart nanoparticles (NPs) that respond to external stimulation, such as light, hyperthermia, and reduction/oxidation, have been developing to achieve optimal drug release in tumor tissues. However, applying these smart NPs to attain high antitumor performance is hampered by limited drug carriers and inefficient spatiotemporal control (spatial, temporal, and dosage control). Here we reported a noninvasive NIR-driven, temperature-sensitive nanoparticles (DI-NPs) co-encapsulating doxorubicin (DOX) and indocyanine green (ICG). This theranostic delivery system applied thermo-responsive lipid to controllably release the drug, utilized the fluorescence (FL) of DOX and ICG to real-time trace the distribution of NPs, and employed DOX/ICG to treat cancer by chemo/photothermal therapy. DI-NPs exhibited uniform size distribution, excellent FL/size stability, enhanced response to temperature and increased drug release by 3 times through laser irradiation. Furthermore, after the endocytosis by MCF-7 breast adenocarcinoma cells, DI-NPs in cellular lyso/endosomes caused hyperthermia through laser irradiation, then endosomes were disrupted and the DI-NPs ‘opened’ to release DOX simultaneously for increased cytotoxicity. DI-NPs also showed long retention time, NIR laser-controlled release of DOX in tumor tissues, and enhanced ICG and DOX accumulation by 7 times and 4 times compared with free drugs. The thermo-sensitive DI-NPs showed a superior efficiency to promote the apoptosis of tumor cells, and completely eradicated tumor without side-effect. This study may provide a new generation of smart strategy for combinatorial cancer therapy. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7438]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Pengfei Zhao,Mingbin Zheng,Zhenyu Luo,et al. Smart Nanomedicine with Spatiotemporal Control for NIR-Triggered Drug Release abd Enhanced Synergistic Antitumor Therapy[C]. 见:ChinaNanomedicine 2015. Hangzhou, China. |
入库方式： OAI收割
来源：深圳先进技术研究院
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