The Step by Step Responsive Nanoparticles for Near-Infrared Imaging and Photothermal Therapy
文献类型：会议论文
| 作者 | Gaofeng Xie; Huqiang Yi; Zexuan Ding; Manyi Ji; Peng Liu; Lintao Cai |
| 出版日期 | 2015 |
| 会议名称 | ChinaNanomedicine 2015 |
| 会议地点 | Hangzhou, China |
| 英文摘要 | Photothermal therapy (PTT) of cancer has drawn great attention owing to its advantages such as minimal invasion, fewer complications and reduced side effects for normal tissues compared to conventional therapies. Here, we developed one kind of step by step responsive nanoparticles (S-S-R NPs) as a smart theranostic platform for noninvasive fluorescence imaging and PTT of cancer. Firstly, Indocyanine green (ICG) wan mixed to poly(cystamine bisacrylamide spermine) [Poly(CBA-SP)] to form redox-responsive nanoparticles, then the nanoparticles were added to a type of charge-conversion polyer-(ethyle glycol)-b-poly(L-lysine)-g-(1,2-dicarboxylic-cyclohexene anhydride) [PEG-b-PLL(DCA)] in water to form the S-S-R NPs which were almost spherical in shape. In the circulation system (pH 7.4), S-S-R NPs would minimize nonspecific interactions with serum components. When under slightly acid pH conditions (pH 6.5), zeta-potentials of the nanoparticles became positively charged, resulting in the formation of shedded nanoparticles. The near-infrared (NIR) images of S-S-R NPs demonstrated that the redox-responsive nanoparticles disassembled and the fluorescence recovered because of the reductive environment in the cytoplasm, which was called the second step responsiveness of the S-S-R NPs. In vitro cellular uptake and PTT efficiency of S-S-R NPs were evaluated using MCF-7 cells. The results showed that change conversion could enhance cell endocytosis of S-S-R NPs under acid environment and when irradiated with laser, the viability of cells decreased rapidly. These results indicated that the S-S-R NPs could be a promising theranostic system for cancer imaging and PTT. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| WOS记录号 | WOS:000373923400350 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7439]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Gaofeng Xie,Huqiang Yi,Zexuan Ding,et al. The Step by Step Responsive Nanoparticles for Near-Infrared Imaging and Photothermal Therapy[C]. 见:ChinaNanomedicine 2015. Hangzhou, China. |
入库方式： OAI收割
来源：深圳先进技术研究院
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