Smart Indocyanine Green Nanoprobe for Imaging-Guided Cancer Phototherapy
文献类型：会议论文
| 作者 | Dehong Hu; Haodong Cui; Jingnan Zhang; Zonghai Sheng; Lintao Cai |
| 出版日期 | 2015 |
| 会议名称 | ChinaNanomedicine 2015 |
| 会议地点 | Hangzhou, China |
| 英文摘要 | Cancer phototherapy has attracted much attention in recent years. To enhance the treatment efficiency of phototherapy and reduce the light-associated side effects, improving drug accumulation and precision guided phototherapy are highly desirable. Herein, we developed a programmed assembly strategy for the preparation of human serum albumin (HSA)-indocyanine green (ICG) nanoparticles (HSA-ICG NPs) by intermolecular disulfide conjugations. Our study indicated that HSA-ICG NPs had a high accumulation with tumor-to-normal tissue ratio of 36.12±5.12 at 24 h and a long-term retention with more than 7 days in xenograft tumors, where the tumor and its margin, normal tissue were be clearly identified via ICG-based in vivo NIR fluorescence imaging and spectrum-resolved technology. Meanwhile, HSA-ICG NPs efficiently induced reactive oxygen species and local hyperthermia simultaneously for synergetic phototherapy. After an intravenous injection of HSA-ICG NPs followed by a single NIR laser dose of 0.8 W/cm2 for 5 min, the tumor was completely suppressed, and no tumor recurrence was observed. Our results suggest programmed assembly of HSA-ICG as a smart theranostic nanoplatform is highly potential for imaging-guided synergetic cancer phototherapy. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| WOS记录号 | WOS:000373923400320 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7447]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Dehong Hu,Haodong Cui,Jingnan Zhang,et al. Smart Indocyanine Green Nanoprobe for Imaging-Guided Cancer Phototherapy[C]. 见:ChinaNanomedicine 2015. Hangzhou, China. |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。