Smart Methylene Blue Nanoprobe for Imaging-Guided Cancer Photodynamic Therapy
文献类型：会议论文
| 作者 | Haodong Cui; Dehong Hu; Liang Huang; Lijiao Ao; Jingnan Zhang; Zonghai Sheng; Lintao Cai |
| 出版日期 | 2015 |
| 会议名称 | ChinaNanomedicine 2015 |
| 会议地点 | Hangzhou, China |
| 英文摘要 | Photodynamic therapy (PDT) is a clinically approved therapeutic modality for the treatment various diseases including cancers. In the present study, we designed a reduction-responsive nanoplatform (BSA-MB NPs) for PDT. Our study indicated that BSA-MB NPs efficiently induced ROS. Meanwhile, BSA-MB NPs had a high accumulation with tumor-to-normal tissue ratio of 36.12±5.12 at 24 h, where the tumor and normal tissue were be clearly identified via MB-based in vivo near-infrared (NIR) fluorescence and photoacoustic dual-modal imaging. After an intravenous injection of BSA-MB NPs followed by photodynamic therapy (660nm, 150mW/cm2 for 30 min), the tumor was completely suppressed, no tumor recurrence and treatments-induced toxicity were observed. The results suggest that BSA-MB NPs generated by programmed assembly as smart theranostic nanoplatforms are highly potential for imaging-guided cancer PDT. We believe that the unique treatment modality could further the therapeutic efficiency of PDT and provide novel opportunities in tumor therapy field. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| WOS记录号 | WOS:000373923400321 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7448]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Haodong Cui,Dehong Hu,Liang Huang,et al. Smart Methylene Blue Nanoprobe for Imaging-Guided Cancer Photodynamic Therapy[C]. 见:ChinaNanomedicine 2015. Hangzhou, China. |
入库方式： OAI收割
来源：深圳先进技术研究院
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