Near-Infrared-Emitting in Vivo pH Nanosensors Based on Doped- Quantum Dots for Fluorescence Lifetime Imaging
文献类型：会议论文
| 作者 | Li Zhang; Chi Chen; Pengfei Zhang; Xiaoqing Meng; Yalin Lv; Lihua Zhou; Ping Gong; Lintao Cai |
| 出版日期 | 2015 |
| 会议名称 | 第十届中美华人纳米论坛(The 10th Sino-US Nano Forum) |
| 会议地点 | Wuhan, China |
| 英文摘要 | pH value is an essential physiological parameter associated with many important chemical or biological processes, such as cell and enzyme activities.[1-2] It could be very challenging for in vivo sensing and imaging pH fluctuations, which is significant for promoting our understanding of pathological processes.[3] As one of noninvasive technologies, optical sensors can provide in situ, fast, quantitative readouts and enable the real-time visualization of parameters which exhibit no intrinsic color or fluorescence.[4] More remarkable, near-infrared (NIR)-emitting fluorescence possesses much high imaging depth than visible-emitting fluorescence, which can be widely explored for in vivo biosensing and bioimaging.[5] Here we prepared Cu-doped CdZnS QDs with ultrasmall size (~3.5 nm), NIR-emitting (~720 nm), and long-decay (lifetime up to ~1 μs) by combining doping and gradiently alloyed nanostructure. Moreover, as-prepared QDs showed excellent pH sensitivity and exhibited a linear response range from pH 5.5 to 7.0 with the maximum change in the fluorescence lifetime up to ~600 ns. Furthermore, the QDs-based in vivo pH imaging has been demonstrated using fluorescence lifetime imaging microscopy (FLIM). It will provide a new candidate of NIR-emitting lifetime based nanosensors for in vivo microenvironment imaging.[6] |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7455]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Li Zhang,Chi Chen,Pengfei Zhang,et al. Near-Infrared-Emitting in Vivo pH Nanosensors Based on Doped- Quantum Dots for Fluorescence Lifetime Imaging[C]. 见:第十届中美华人纳米论坛(The 10th Sino-US Nano Forum). Wuhan, China. |
入库方式： OAI收割
来源：深圳先进技术研究院
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