Using high strength hydrogel to repair the cartilage in the loading area
文献类型：会议论文
| 作者 | Xiaoli Zhao; Sheng Zhang; Wenguang Liu; William W Lu |
| 出版日期 | 2015 |
| 会议名称 | 5th China-Europe Symposium on Biomaterials in Regenerative Medicine, CESB |
| 会议地点 | 浙江杭州 |
| 英文摘要 | Osteoarthritis (OA), the most common form of arthritis, is a debilitating and progressive disease that has become a major cause of disability and impaired quality of life in the elderly.[1] Osteoarthritis often becomes chronic, and conventional treatments have demonstrated only modest clinical benefits without lesion reversal. Though there are several different techniques available for the treatment of full-thickness defects such as microfracture, mosaicplasty, ACI etc., these techniques usually have some limitations. Further deterioration of the osteoarthritis could only resort to joint replacement. So there is urgent need for novel technique in the treatment of osteoarthritis. Encouragingly, the development of novel mechanically strong hydrogel solved the problem of poor mechanical properties of tradition hydrogel, making it possibly applied in hard tissue repair. In this study, the high strength hydrogel was fabricated by one-step photopolymerization of acrylonitrile and 2-methacryloyloxyethyl phosphorylcholine with the crosslinker of polyethylene glycol diacrylate to form the double network hydrogel. During the reaction, hydroxyapatite micro particles were added to create the mechanical gradient and enhance the biocompatibility. The mechanical properties, the compatibility and cell attachment of the prepared hydrogel were evaluated. The results showed that the water content of hydrogel reached 70~80%. The Young modulus of the hydrogel could reach 1 MPa, and the hydroxyapatite could further enhance the Young modulus to 2MPa. These properties present by hydrogel resemble to the nature cartilage. At the same time, hydrogel maintained good cell viability. The morphology of the cell attached on the hydrogel was observed by SEM and confocal microscopy, it could be observed that the hydroxyapatite modification improved the cell attachment. Entocondyle cartilage defect model on SD rat was used to evaluate the hydrogel repair effect in the loading area. Three months later, the morphylogy of the hydrogel was preserved well as observed. These preliminary results showed that the high strength hydrogel present the resemblant properties to nature cartilage and showed good biocompatibility both in vitro and in vivo. This provides the novel technique for possible treatment in delaying and preventing the further deterioration of osteoarthritis. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7470]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2015 |
| 推荐引用方式 GB/T 7714 | Xiaoli Zhao,Sheng Zhang,Wenguang Liu,et al. Using high strength hydrogel to repair the cartilage in the loading area[C]. 见:5th China-Europe Symposium on Biomaterials in Regenerative Medicine, CESB. 浙江杭州. |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。