Tumor targeted nanoparticle drug delivery system from partial VAR2CSA peptide conjugatedN-2-hydroxypropyl trimethyl ammonium chloride chitosan
文献类型：会议论文
| 作者 | Guogang Cheng; Dan Li; Jinyu Han; Jie Chen; Baobei Wang; Mengxia Li; Tianxia Xiao; Kai Zhao; Xiujun Fan |
| 出版日期 | 2016 |
| 会议名称 | The 4th SKLRB Symposium on Reproductive Biology |
| 会议地点 | 中国北京 |
| 英文摘要 | To efficiently deliver anti-cancer drug to tumor site and reduce its toxic side effects on normal tissues, the partial VAR2CSA peptide decorated and tumor microenvironment triggering cascade pH-responsive chitosan derivative drug delivery system was fabricated. A cationic polymer N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC) and VAR2CSA-N-2-hydroxypropyl trimethyl ammonium chloride chitosan (CSA-N-2-HACC) were synthesized and characterized. And VAR2CSA peptide is served as targeting peptide for nanoparticles that can be specifically binds a distinct type chondroitin sulfate expressed in the placenta and most type of tumors. Strain HDZK-BYSB107 prodigiosin/CSA-N-2-HACC- nanoparticles (PG/CSA-N-2-HACC-NPs) were prepared by ionic-crosslinking method with carboxymethyl chitosan and then characterized according to morphology, size, and zeta potential. PG/CSA-N-2-HACC-NPs presented pH-triggered drug release behavior under acidic conditions. The accumulation of nanoparticles detected by laser confocal fluorescence microscopy and flow cytometry showed that CSA-N-2-HACC-NPs was easily taken up by JEG-3, PC-3, and A549 cells. CCK-8 assays studies revealed that cell viability was significantly inhibited by PG/CSA-N-2-HACC-NPs. More importantly, in vivo animal studies showed that PG/CSA-N-2-HACC-NPs exhibited better anti-tumor activity and lower toxic effect in subcutaneous choriocarcinoma, prostate, and non-small-cell lung cancer models compared with other groups. These results suggested that PG/CSA-N-2-HACC-NPs had better cancer targeting capacity and superior anti-tumor efficacy. Thus, this nanparticles delivery system has great potential as a novel carrier in delivering anti-tumor drugs. |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/10831]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | 2016 |
| 推荐引用方式 GB/T 7714 | Guogang Cheng,Dan Li,Jinyu Han,et al. Tumor targeted nanoparticle drug delivery system from partial VAR2CSA peptide conjugatedN-2-hydroxypropyl trimethyl ammonium chloride chitosan[C]. 见:The 4th SKLRB Symposium on Reproductive Biology. 中国北京. |
入库方式： OAI收割
来源：深圳先进技术研究院
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