Evidence of AS3MT d2d3 -Associated Variants within 10q24.32–33 in the Genetic Risk of Major Affective Disorders
文献类型：期刊论文
| 作者 | Li LY[; Chang H; Peng T; Li M[*]; Xiao X[*] |
| 刊名 | Molecullar Neuropsychiatry
 |
| 出版日期 | 2016 |
| 卷号 | 2期号:X页码:213–218 |
| 关键词 | 10q24.32–33 · AS3MT d2d3 Schizophrenia Major affective |
| 通讯作者 | xiaoxiao2mail.kiz.ac.cn |
| 英文摘要 | Genome-wide association studies suggest that 10q24.32–33 is a risk region for schizophrenia (SCZ). Considering the substantial genetic overlap between SCZ and major affective disorders, we would like to investigate whether the 10q24.32–33 region confers risk of affective disorders. We chose three SCZ genome-wide significant SNPs (rs7914558,rs7085104, and rs11191580) in 10q24.32–33 and collected the statistical data from European and Asian populations to perform systematic meta-analyses, which finally included up to 26,413 cases with affective disorders and 24,849 controls. Meta-analyses showed that all SNPs were nominally associated with major affective disorders. Considering the a priori evidence that these SNPs were associated with the expression of AS3MT d2d3 isoform in the human brain, our data con- firms the potential involvement of AS3MT d2d3 in the geneticrisk of major affective disorders. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10949]  |
| 专题 | 昆明动物研究所_转化基因组 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming , China |
| 推荐引用方式 GB/T 7714 | Li LY[,Chang H,Peng T,et al. Evidence of AS3MT d2d3 -Associated Variants within 10q24.32–33 in the Genetic Risk of Major Affective Disorders[J]. Molecullar Neuropsychiatry,2016,2(X):213–218. |
| APA | Li LY[,Chang H,Peng T,Li M[*],&Xiao X[*].(2016).Evidence of AS3MT d2d3 -Associated Variants within 10q24.32–33 in the Genetic Risk of Major Affective Disorders.Molecullar Neuropsychiatry,2(X),213–218. |
| MLA | Li LY[,et al."Evidence of AS3MT d2d3 -Associated Variants within 10q24.32–33 in the Genetic Risk of Major Affective Disorders".Molecullar Neuropsychiatry 2.X(2016):213–218. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。