(±)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum
文献类型：期刊论文
| 作者 | Li L1,2; Li H2,3; Dong JR1,2; Yu MY1,2; Li XN1; Zhou L1; Yang J[*]3; Qiu MH[*]1,2; Peng XR1; Hou B1,2 |
| 刊名 | Organic Letters
 |
| 出版日期 | 2016 |
| 卷号 | 18期号:X页码:6078−6081 |
| 通讯作者 | jianyang@mail.kiz.ac.cn ; mhchiu@mail.kib.ac.cn |
| 英文摘要 |
(±)-Ganoapplanin (1), a pair of novel meroterpenoid enantiomers featuring an unprecedented dioxaspirocyclic skeleton constructed from a 6/6/6/6 tetracyclic system and an unusual tricyclo[4.3.3.0 3 ′ ,7 ′ ]dodecane motif, were isolated from Ganoderma applanatum. Its structure and absolute configurations were determined by spectroscopic analyses, X-ray crystallography, and ECD (electronic circular dichroism
calculations). A plausible biogenetic pathway, involving a key Gomberg0Bachmann reaction, was also proposed for (±)-1. Biological studies showed that (±)-1 and its enantiomers exhibited different inhibitory activities on T-type voltage-gated calcium channels. |
| 收录类别 | SCI |
| 资助信息 | The project was financially supported by the General Program of NSFC (No. 81172940) and Knowledge Innovation Program of the CAS (Grant No. KSZD-EW-Z-004-01, KSCX2-YW-R- 194), the Instrument Developing Project of the CAS (2011), and the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2010-ZZ14). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10950]  |
| 专题 | 昆明动物研究所_离子通道药物研发中心 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China 2.Graduate University of the Chinese Academy of Sciences, Beijing 100049, People’s Republic of China 3.Key Laboratory of Animal Models and Human Disease Mechanisms, and Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Li L,Li H,Dong JR,et al. (±)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum[J]. Organic Letters,2016,18(X):6078−6081. |
| APA | Li L.,Li H.,Dong JR.,Yu MY.,Li XN.,...&Yu MY.(2016).(±)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum.Organic Letters,18(X),6078−6081. |
| MLA | Li L,et al."(±)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from Ganoderma applanatum".Organic Letters 18.X(2016):6078−6081. |
入库方式： OAI收割
来源：昆明动物研究所
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