TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy
文献类型：期刊论文
| 作者 | Su DY1,2; Zhao H1; Zhou M1,4; Yang J[*]1,5; Wang S[*]1,2; Hu JS1,2; Tang D1; Cui JM1,3 |
| 刊名 | EMBO Rep
 |
| 出版日期 | 2016 |
| 卷号 | 17期号:10页码:1422-1430 |
| 关键词 | TRPA1 TRPV1 allergy iodine pain |
| 通讯作者 | jianyang@mail.kiz.ac.cn ; jy160@columbia.edu ; wangshu@mail.kiz.ac.cn |
| 英文摘要 | Iodine antiseptics exhibit superior antimicrobial efficacy and do not cause acquired microbial resistance. However, they are underused in comparison with antibiotics in infection treatments, partly because of their adverse effects such as pain and allergy. The cause of these noxious effects is not fully understood, and no specific molecular targets or mechanisms have been discovered. In this study, we show that iodine antiseptics cause pain and promote allergic contact dermatitis in mouse models, and iodine stimulates a subset of sensory neurons that express TRPA1 and TRPV1 channels. In vivo pharmacological inhibition or genetic ablation of these channels indicates that TRPA1 plays a major role in iodine antiseptics-induced pain and the adjuvant effect of iodine antiseptics on allergic contact dermatitis and that TRPV1 is also involved. We further demonstrate that iodine activates TRPA1 through a redox mechanism but has no direct effects on TRPV1. Our study improves the understanding of the adverse effects of iodine antiseptics and suggests a means to minimize their side effects through local inhibition of TRPA1 and TRPV1 channels. |
| 资助信息 | This work was supported by a grant from the High-level Over- seas Talents of Yunnan Province to Jianmin Cui; grants from the High-level Overseas Talents of Yunnan Province and the National Basic Research Program of China (2014CB910301) to Ming Zhou; grants from the Top Talents Program of Yunnan Province (2011HA012), National Basic Research Program of China (2014CB910301), High-level Overseas Talents of Yunnan Province, Yunnan Major Science and Technology Project (2015ZJ002), and the National Natural Science Foundation of China (NSFC) (31370821) to Jian Yang; and grants from the National Natural Science Foundation of China (81302865), Key Research Program of the Chinese Academy of Sciences (KJZD-EW-L03), West Light Foun- dation of the Chinese Academy of Sciences, Yunnan Applied Basic Research Projects (2013FB074), and Youth Innovation Promotion Association of the Chinese Academy of Sciences to Shu Wang. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10955]  |
| 专题 | 昆明动物研究所_离子通道药物研发中心 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, and Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 3.Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, USA 4.Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA 5.Department of Biological Sciences, Columbia University, New York, NY, USA |
| 推荐引用方式 GB/T 7714 | Su DY,Zhao H,Zhou M,et al. TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy[J]. EMBO Rep,2016,17(10):1422-1430. |
| APA | Su DY.,Zhao H.,Zhou M.,Yang J[*].,Wang S[*].,...&Cui JM.(2016).TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy.EMBO Rep,17(10),1422-1430. |
| MLA | Su DY,et al."TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy".EMBO Rep 17.10(2016):1422-1430. |
入库方式： OAI收割
来源：昆明动物研究所
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