NCAPH plays important roles in human colon cancer
文献类型：期刊论文
| 作者 | Yin L1,2; Jiang LP3,4; Zhang LL5; Yu HJ5; Guo X6; Luo Y6; Dong J[*]2; Kong QP[*]7; Shen QS3,4; Yang CP[*]3 |
| 刊名 | Cell Death and Disease
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:X页码:e2680 |
| 通讯作者 | ybchen@mail.kiz.ac.cn ; cuipingyang@mail.kiz.ac.cn ; kongqp@mail.kiz.ac.cn |
| 英文摘要 | Colon cancer (CC) is one of the major malignancies worldwide, whose pathogenesis is complex and requires the accumulated alteration of multiple genes and signaling pathways. Condensins are multi-protein complexes that play pivotal roles in chromosome assembly and segregation during mitosis, meiosis and even tumorigenesis. Using tissue microarrays by immunohistochemistry and hematoxylin-eosin staining, we found that non-SMC condensin I complex subunit H (NCAPH) in colon cancerous tissues was higher than that in all corresponding adjacent non-cancerous tissues. We then characterized the exact function of the NCAPH in CC. We provided evidences showing that NCAPH is highly expressed in colorectal cancer cell lines comparing with normal human colonic epithelial cells, and identified many NCAPH mutations in CC patients. We found that depletion of NCAPH inhibits CC cell proliferation, migration in vitro and xenograft tumor formation in vivo. Furthermore, NCAPH knockdown promotes cell apoptosis and cell cycle arrest at G2/M phase. Interestingly, the NCAPH high expression in tumor tissues of colon patients had a significantly better prognosis and survival rate than low-expression patients, suggesting that NCAPH high expression promotes colonic cancerous cell proliferation; on the other hand, it may also sensitize these cells responding to chemo- or radio-therapies. Collectively, these findings reveal an important role of NCAPH in CC, indicating that NCAPH could be used as a new therapeutic target in future. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Key Research and Development Program of China, Stem Cell and Translational Research (2016YFA0100900), Strategic Priority Research Program of the ChineseAcademyof Sciences (XDB13000000) and National Nature Science Foundation of China (U1502224 and 81672764,31471187),and YunnanAppliedBasicResearchProjects (2014FA038,2016FA009,2014FB182and2014FZ019).C.P.Y.wasalsosupportedby the Chinese Academy of Sciences Western Light Program, Youth Innovation Promotion Association, CAS. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10980]  |
| 专题 | 昆明动物研究所_分子人类学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_肿瘤信号转导 |
| 作者单位 | 1.The First Affiliated Hospital of Kunming Medical University, Kunming 650223, China 2.The Third Affiliated Hospital of Kunming Medical University, Kunming 650223, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Jiao Chang Dong Lu 32, Kunming 650223, China 4.Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China 5.College of Life Sciences, Yunnan University, Kunming 650091, China. 6.Faculty of Medicine, Kunming University of Science & Technology, Chenggong County, Kunming 650500, China 7.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. |
| 推荐引用方式 GB/T 7714 | Yin L,Jiang LP,Zhang LL,et al. NCAPH plays important roles in human colon cancer[J]. Cell Death and Disease,2017,8(X):e2680. |
| APA | Yin L.,Jiang LP.,Zhang LL.,Yu HJ.,Guo X.,...&Zhuo X.(2017).NCAPH plays important roles in human colon cancer.Cell Death and Disease,8(X),e2680. |
| MLA | Yin L,et al."NCAPH plays important roles in human colon cancer".Cell Death and Disease 8.X(2017):e2680. |
入库方式： OAI收割
来源：昆明动物研究所
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