Association study of promoter polymorphisms in the CETP gene with longevity in the Han Chinese population
文献类型：期刊论文
| 作者 | Yang JK1; Gong YY2; Zhang YP1,2; Xie L2; Yang Y3; Xu LY4 |
| 刊名 | Molecular Biology Reports
 |
| 出版日期 | 2014 |
| 卷号 | 41期号:X页码:325–329 |
| 关键词 | Longevity CETP Polymorphisms Han Chinese population |
| 通讯作者 | zhangyp@mail.kiz.ac.cn |
| 英文摘要 | The cholesteryl ester transfer protein (CETP), which is involved in the regulation of reverse cholesterol transport and metabolism of high-density lipoprotein cholesterol, has been proposed as a candidate gene for human longevity. SNPs in the promoter region of the CETP gene is likely important in regulation of the expression of the CETP gene. To explore the potential effects of the promoter polymorphisms in the CETP gene on longevity, we investigated the promoter polymorphisms in a sample of long-lived (≥ 90 years old) Han Chinese collected from Southwestern China (N = 380). By resequencing 934 bp of the promoter region, genotypes of four SNPs (-573A/G, -629A/C, -971A/G, -1046T/C) were examined in this sample. However, no association could be confirmed between longevity and these SNPs or haplotypes inferred from them. A novel rare variant -573A/G was found and was found in heterozygote state only in five persons in the Longevity group. But it was not statistically significant (p = 0.075). We also examined this novel polymorphism -573A/G in another Han Chinese sample from Yunnan province, and it was not associated with longevity. The results from both samples suggest that there is likely no association of the CETP gene promoter polymorphisms with longevity, at least among Han Chinese. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National Natural Science Foundation of China. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11002]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_分子进化基因组学 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, People’s Republic of China 2.State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People’s Republic of China 3.Key Laboratory of Animal Models and Human Disease Mechanisms and Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People’s Republic of China 4.Dujiangyan Longevity |
| 推荐引用方式 GB/T 7714 | Yang JK,Gong YY,Zhang YP,et al. Association study of promoter polymorphisms in the CETP gene with longevity in the Han Chinese population[J]. Molecular Biology Reports,2014,41(X):325–329. |
| APA | Yang JK,Gong YY,Zhang YP,Xie L,Yang Y,&Xu LY.(2014).Association study of promoter polymorphisms in the CETP gene with longevity in the Han Chinese population.Molecular Biology Reports,41(X),325–329. |
| MLA | Yang JK,et al."Association study of promoter polymorphisms in the CETP gene with longevity in the Han Chinese population".Molecular Biology Reports 41.X(2014):325–329. |
入库方式： OAI收割
来源：昆明动物研究所
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