A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys
文献类型：期刊论文
| 作者 | Dai PM1,2; Huang H1,3; Yang FH1; Zhao N5; Yang JZ1; Ge LJ1; Lin Y1; Yu HL[*]5; Zhang L1,4,5; Wang JH[*]1 |
| 刊名 | Scientific Reports
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:X页码:e45097 |
| 通讯作者 | Yuhl308@126.com ; wangjh@mail.kiz.ac.cn |
| 英文摘要 | Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has numerous advantages to the rodent and marmoset that make it a superior and irreplaceable animal model for studying stroke in the brain. In the present study, after mapping the preferred hand representation in two healthy male monkeys with intracortical micro-stimulation, ET-1 was microinjected into the contralateral motor cortex (M1) to its preferred hand. The monkeys had been trained in three manual dexterity tasks before the microinjection and were tested for these tasks following the ET-1 injection. Brain Magnetic Resonance Imaging scans were performed 1, 7, 14 and 28 days post ischemia. It was found that ET-1 impaired the manual dexterity of the monkeys in the vertical slot and rotating Brinkman board tasks 3-8 days after the injection. Brain imaging found that severe edema was present 7 days after the focal ischemia. This data suggest that ET-1 can induce transient ischemic stroke in rhesus monkey and that ET-1 induced focal ischemia in non-human primates is a potential model to study the mechanism of stroke and brain repair after stroke. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Science Foundation of China (NSFC 31571109, 31271168), 973 program (2015CB856401), the Yunnan Key Program of Science, Technology (2014FC005), the Chinese-Finnish Joint Project (813111172) and Hainan special fund project for science and technology (KJHZ2015-20). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11006]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_神经系统编码 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Primates Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Department of Neurosurgery, First People’s Hospital of Honghe State, Honghe, China 3.Department of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang, China 4.Department of Neurosurgery, Center People’s Hospital of Zhumadian State, Zhumadian, China 5.Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, China 6.Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China 7.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Dai PM,Huang H,Yang FH,et al. A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys[J]. Scientific Reports,2017,7(X):e45097. |
| APA | Dai PM.,Huang H.,Yang FH.,Zhao N.,Yang JZ.,...&Zhao XD.(2017).A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys.Scientific Reports,7(X),e45097. |
| MLA | Dai PM,et al."A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys".Scientific Reports 7.X(2017):e45097. |
入库方式： OAI收割
来源：昆明动物研究所
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