Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response
文献类型：期刊论文
| 作者 | Liu XL1,2; Yang XC1,2; Ma PC[*]1; Mao BY[*]1; Li YX1,2; Zhao SH3; Li CC1 |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2016 |
| 卷号 | 590期号:23页码:4213-4222 |
| 关键词 | cycle DNA damage response Polyubiquitination Trip12 USP7 |
| 通讯作者 | kunmapch@mail.kiz.ac.cn ; mao@mail.kiz.ac.cn |
| 英文摘要 | The deubiquitinating enzyme, USP7/HAUSP (herpesvirus-associated ubiquitin-specific protease), is a key regulator of the tumor suppressor p53 and plays a major role in regulating genome stability. Here, we report that the protein stability of USP7 is regulated by the ubiquitin-proteasome pathway. We identified the thyroid hormone receptor interactor 12 (Trip12) as a ubiquitin E3 ligase for USP7. We also found that Trip12 affects USP7-mediated stabilization of p53 and the checkpoint proteins 53BP1 and Chk1. Knockdown of Trip12 leads to an increased cell population in G1 phase, mimicking USP7 overexpression. In contrast, Trip12 overexpression increased the number of cells in intra-S-phase, phenocopying the USP7 knockdown phenotype. Therefore, our data reveal an important modulatory role for Trip12 in the USP7-dependent DNA damage response. |
| 收录类别 | SCI |
| 资助信息 | This work was support by grants from The West Light Foundation of The Chinese Academy of Sciences, The National Natural Science Foundation of China (No. 31500847 to P.C.M and No.81300542 to S.H.Z), and Yunnan Applied Basic Research Pro- ject (No. 2016FB043). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10896]  |
| 专题 | 昆明动物研究所_发育生物学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, China 3.Yunnan Population and Family Planning Research Institute, Kunming, China |
| 推荐引用方式 GB/T 7714 | Liu XL,Yang XC,Ma PC[*],et al. Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response[J]. FEBS LETTERS,2016,590(23):4213-4222. |
| APA | Liu XL.,Yang XC.,Ma PC[*].,Mao BY[*].,Li YX.,...&Li CC.(2016).Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response.FEBS LETTERS,590(23),4213-4222. |
| MLA | Liu XL,et al."Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response".FEBS LETTERS 590.23(2016):4213-4222. |
入库方式： OAI收割
来源：昆明动物研究所
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