Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
文献类型：期刊论文
| 作者 | Zheng HY1,2; Zhang MX1,3; Lian XD1,3; Tian RR1; Zhang XL1; Zhang LT1; Pang W1; Zhang GH1; Chen M1,3; Zheng YT[*]1,2,3,5 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:X页码:e37 |
| 通讯作者 | zhengyt@mail.kiz.ac.cn |
| 英文摘要 | The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging. However, this hypothesis remains to be fully tested. Here, we studied 6 young and 12 old Chinese rhesus macaques (ChRM) over the course of three months after simian immunodeficiency virus (SIV) SIVmac239 infection. Old ChRM showed a higher risk of accelerated AIDS development than did young macaques, owing to rapidly elevated plasma viral loads and decreased levels of CD4+ T cells. The low frequency of naïve CD4+ T cells before infection was strongly predictive of an increased disease progression, whereas the severe depletion of CD4+ T cells and the rapid proliferation of naïve lymphocytes accelerated the exhaustion of naïve lymphocytes in old ChRM. Moreover, in old ChRM, a robust innate host response with defective regulation was associated with a compensation for naïve T cell depletion and a high level of immune activation. Therefore, we suggest that immunosenescence plays an important role in the accelerated AIDS progression in elderly individuals and that SIV-infected old ChRM may be a favorable model for studying AIDS pathogenesis and researching therapies for elderly AIDS patients. |
| 资助信息 | The work was supported by the National Natural Science Foundation of China (81671627; 81172876; 81273251; 81471620; 81571606; U1202228), the Knowledge Innovation Program of CAS (KJZD-EW-L10-02; KSCX2- EW-R-13), the National Basic Research Program of China (2 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10907]  |
| 专题 | 昆明动物研究所_分子免疫药理学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences &Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China 2.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650204, China 4.Institute of Health Sciences, Anhui University, Hefei, Anhui, 230601, China 5.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China |
| 推荐引用方式 GB/T 7714 | Zheng HY,Zhang MX,Lian XD,et al. Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence[J]. SCIENTIFIC REPORTS,2017,7(X):e37. |
| APA | Zheng HY.,Zhang MX.,Lian XD.,Tian RR.,Zhang XL.,...&Song JH.(2017).Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence.SCIENTIFIC REPORTS,7(X),e37. |
| MLA | Zheng HY,et al."Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence".SCIENTIFIC REPORTS 7.X(2017):e37. |
入库方式： OAI收割
来源：昆明动物研究所
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