The comparative analysis of the energies of conjugated triple base triplets and their applications
文献类型：期刊论文
| 作者 | Liu SQ1; Yang J1; Bai CL2; Liu CQ[*]1,3 |
| 刊名 | JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
 |
| 出版日期 | 2002 |
| 卷号 | 578期号:X页码:215-219 |
| 关键词 | conjugated TBT energy comparative analysis applications |
| ISSN号 | 0166-1280 |
| 产权排序 | The comparative analysis of the energies of conjugated triple base triplets and their applications |
| 通讯作者 | tbrg@public.km.yn.cn |
| 中文摘要 | We built 64 sets of 3D models of DNA triplex base triplets (TBT) and minimized their energies. The TBTs were divided into 32 pairs of conjugated ones on the basis of their sequence characteristic, and the energies of each pair of them were compared and analyzed, the results showed: (i) The duplex DNA of which any strand contains at least a couple of A or T, has a preference for selecting the oligodeoxyribonucleic acid (ODN) strand containing abundant T to form TBT. (ii) The duplex DNA of which any strand contains at least a couple of G or C has a preference for selecting ODN containing abundant G to form symmetric antiparallel TBT, but selecting ODN containing abundant C to form asymmetric parallel TBT. (iii) The duplex DNA of which any strand contains only one of A, T, G or C has a preference for selecting ODN containing abundant pyrimidines (T or C) to form antiparallel TBT. Additionally, two examples of TBTs applications, in designing ODN to form triplex with duplex were presented. The energy calculation result revealed that 15-TCG is the best ligand of the HIV PPT duplex. The comparative analysis of energies of the conjugated TBTs provides directive significance for designing ODN strand that is easy to form triplex in theory. (C) 2002 Elsevier Science B.V. All rights reserved. |
| 收录类别 | SCI |
| 原文出处 | 2002578215.pdf |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5251]  |
| 专题 | 昆明动物研究所_其他 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming 650223, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100081, Peoples R China 3.Yunnan Univ, Modern Biol Ctr, Kunming 650091, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu SQ,Yang J,Bai CL,et al. The comparative analysis of the energies of conjugated triple base triplets and their applications[J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,2002,578(X):215-219. |
| APA | Liu SQ,Yang J,Bai CL,&Liu CQ[*].(2002).The comparative analysis of the energies of conjugated triple base triplets and their applications.JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,578(X),215-219. |
| MLA | Liu SQ,et al."The comparative analysis of the energies of conjugated triple base triplets and their applications".JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM 578.X(2002):215-219. |
入库方式： OAI收割
来源：昆明动物研究所
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