Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets
文献类型：期刊论文
| 作者 | Li WX1; Dai SX2,3; Zheng JJ2,3; Liu JQ2,3; Liu DH[*]4; Li GH[*]2,3; Huang JF[*]2,3,5,6; Wang Q2,3; Guo YC2; Hong Y4 |
| 刊名 | PeerJ
 |
| 出版日期 | 2016 |
| 卷号 | 4期号:X页码:e2470 |
| 关键词 | Sex and age difference, Anti-stroke target Ischemic stroke |
| 通讯作者 | seansean2014@126.com ; ligonghua@mail.kiz.ac.cn ; huangjf@mail.kiz.ac.cn |
| 英文摘要 | Ischemic stroke is a common neurological disorder and the burden in the world is growing. This study aims to explore the effect of sex and age difference on ischemic stroke using integrated microarray datasets. The results showed a dramatic difference in whole gene expression profiles and influenced pathways between males and females, and also in the old and young individuals. Furthermore, compared with old males, old female patients showed more serious biological function damage. However, females showed less affected pathways than males in young subjects. Functional interaction networks showed these differential expression genes were mostly related to immune and inflammation-related functions. In addition, we found ARG1 and MMP9 were up-regulated in total and all subgroups. Importantly, IL1A, ILAB, IL6 and TNF and other anti-stroke target genes were up-regulated in males. However, these anti-stroke target genes showed low expression in females. This study found huge sex and age differences in ischemic stroke especially the opposite expression of anti-stroke target genes. Future studies are needed to uncover these pathological mechanisms, and to take appropriate pre-prevention, treatment and rehabilitation measures. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Basic Research Program of China (Grant No. 2013CB835100) and the National Natural Science Foundation of China (Grant No. 81570376, No. 31401142 and No. 31401137). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10952]  |
| 专题 | 昆明动物研究所_结构生物信息学 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.Institute of Health Sciences, Anhui University, Hefei, Anhui, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China 4.Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei, Anhui, China 5.KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, Kunming, Yunnan, China 6.Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Li WX,Dai SX,Zheng JJ,et al. Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets[J]. PeerJ,2016,4(X):e2470. |
| APA | Li WX.,Dai SX.,Zheng JJ.,Liu JQ.,Liu DH[*].,...&Hong Y.(2016).Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets.PeerJ,4(X),e2470. |
| MLA | Li WX,et al."Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets".PeerJ 4.X(2016):e2470. |
入库方式： OAI收割
来源：昆明动物研究所
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