Different impairment of immune and inflammation functions in short and long-term after ischemic stroke
文献类型：期刊论文
| 作者 | Li WX1,2; Qi F3; Zhang T5; Cheng F5; Liu DH5; Zheng SG6; Liu JQ2,4; Li GH2,4; Dai SX2,4 |
| 刊名 | American Journal Translational Research
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:2页码:736-745 |
| 关键词 | Ischemic stroke time periods immune and inflammation biological functions gene expression |
| 英文摘要 | Ischemic stroke therapy and prognosis outcomes largely depend on the time periods after symptom onset. This study aims to explore the difference of global gene expression profiles and impairment of biological functions between short-term and long-term after stroke onset. We compared three short-term (3 h, 5 h and 24 h) and a long-term (6-month) gene expression levels by a multi-platform microarray data integration method. RankProd was used to calculate the differentially expressed genes between stroke patients and controls. DAVID Bioinformatics Resources was utilized to determine affected biological functions. Consensus cluster and hierarchical cluster methods were employed to compare the gene expression patterns of the commonly biological functions among these four time course groups. The results showed that severe impairment of inflammation and immune related functions in 5 h and 24 h after symptom onset. However, these functions were less affected in the 3 h and the 6-month groups. In addition, several key genes (CCL20, THBS1, EREG, and IL6 et al.) were dramatically down-regulated in 5 h and 24 h groups, whereas these genes showed no change or even a slight contrary expression in 3 h or 6-month groups. This study has identified the large differences of altered immune and inflammation functions based on gene levels between short and long-term after stroke onset. The findings provide valuable insight into the clinical practice and prognosis evaluation of ischemic stroke. |
| 收录类别 | 其他 |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (Grant No. 81570376, No. 31401142 and No. 31401137). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10999]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_结构生物信息学 |
| 作者单位 | 1.Institute of Health Sciences, Anhui University, Hefei 230601, Anhui, China 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yun- nan, China 3.Department of Respiratory Medicine, Guizhou Medical University, Guiyang 550004, Guizhou, China 4.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, Yunnan, China 5.Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei 230601, Anhui, China 6.Division of Rheumatology, Department of Medicine, Milton S. Hershey Medical Center at Penn State Un- versity, Hershey, 17036, USA |
| 推荐引用方式 GB/T 7714 | Li WX,Qi F,Zhang T,et al. Different impairment of immune and inflammation functions in short and long-term after ischemic stroke[J]. American Journal Translational Research,2017,9(2):736-745. |
| APA | Li WX.,Qi F.,Zhang T.,Cheng F.,Liu DH.,...&Dai SX.(2017).Different impairment of immune and inflammation functions in short and long-term after ischemic stroke.American Journal Translational Research,9(2),736-745. |
| MLA | Li WX,et al."Different impairment of immune and inflammation functions in short and long-term after ischemic stroke".American Journal Translational Research 9.2(2017):736-745. |
入库方式： OAI收割
来源：昆明动物研究所
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