Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol
文献类型：期刊论文
| 作者 | He DX1; Gu F2; Mao AQ4; Zhang GY1; Ding ZY1; Wang JK3; Hao JJ[*]5; Fu L[*]2; Wu J3; Ma X[*]4 |
| 刊名 | Clinical Science
 |
| 出版日期 | 2016 |
| 卷号 | 130期号:24页码:2267–2276 |
| 关键词 | chemoresistance dicumarol pregnancy specific beta-1-glycoprotein 1 (PSG1) |
| 通讯作者 | maxin@jiangnan.edu.cn ; fulijyb@hotmail.com ; haojunjun@mail.kiz.ac.cn |
| 英文摘要 | Chemotherapeutic response is critical for the successful treatment and good prognosis in cancer patients. In this study, we analysed the gene expression profiles of preoperative samples from oestrogen receptor (ER)-negative breast cancer patients with different responses to taxane-anthracycline-based (TA-based) chemotherapy, and identified a group of genes that was predictive. Pregnancy specific beta-1-glycoprotein 1 (PSG1) played a central role within signalling pathways of these genes. Inhibiting PSG1 can effectively reduce chemoresistance via a transforming growth factor-β (TGF-β)-related pathway in ER-negative breast cancer cells. Drug screening then identified dicumarol (DCM) to target the PSG1 and inhibit chemoresistance to TA-based chemotherapy in vitro, in vivo, and in clinical samples. Taken together, this study highlights PSG1 as an important mediator of chemoresistance, whose effect could be diminished by DCM. |
| 资助信息 | This work was supported by the China National Natural Science Foundation [grant numbers 81572940, 81622007 and 91439131 (to X.M.), 31550006 (to D.-x.H.)]; the Natural Science Founda- tion for Distinguished Young Scholars of Jiangsu Province [grant number BK20140004 (to X.M.)]; the National High Technology Re- search and Development Program (863 Program) of China [grant number SQ2015AA020948 (to X.M.)]; and Fundamental Research Funds for the Central Universities [grant numbers JUSRP51311A and JUSRP51615B (to X.M. and D.-x.H.)]. |
| 源URL | [http://159.226.149.26:8080/handle/152453/10997]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_进化与功能基因组学 |
| 作者单位 | 1.National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China 2.Department of Breast Cancer Pathology and Research Laboratory, State Key Laboratory of Breast Cancer Research, Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China 3.State Key Laboratory of Bioelectronics, Southeast University Sipailou 2#, Nanjing 210096, China 4.Department of Cellular and Molecular Pharmacology, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China 5.State Key Lab of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | He DX,Gu F,Mao AQ,et al. Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol[J]. Clinical Science,2016,130(24):2267–2276. |
| APA | He DX.,Gu F.,Mao AQ.,Zhang GY.,Ding ZY.,...&Lu CX.(2016).Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol.Clinical Science,130(24),2267–2276. |
| MLA | He DX,et al."Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol".Clinical Science 130.24(2016):2267–2276. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。