E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells
文献类型：期刊论文
| 作者 | Jones-Mason ME1; Zhao XD2; Kappes D6; Lasorella A2,3,4; Iavarone A2,3,5; Zhuang Y[*]1 |
| 刊名 | IMMUNITY
 |
| 出版日期 | 2012 |
| 卷号 | 36期号:3页码:348-361 |
| 通讯作者 | yzhuang@duke.edu |
| 英文摘要 | The double-positive (DP) to single-positive (SP) transition during T cell development is initiated by downregulation of the E protein transcription factors HEB and E2A. Here, we have demonstrated that in addition to regulating the onset of this transition, HEB and E2A also play a separate role in CD4(+) lineage choice. Deletion of HEB and E2A in DP thymocytes specifically blocked the development of CD4(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 allowed CD4(+) T cell development but blocked CD8(+) lineage development. Analysis of the CD4(+) lineage transcriptional regulators ThPOK and Gata3 placed HEB and E2A upstream of CD4(+) lineage specification. These studies identify an important role for E proteins in the activation of CD4(+) lineage differentiation as thymocytes undergo the DP to SP transition. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2014-07-07 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7938]  |
| 专题 | 昆明动物研究所_科研共享资源 |
| 作者单位 | 1.Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA 2.Institute for Cancer Genetics,Columbia University Medical Center, New York, NY 10032, USA 3.Department of Pathology,Columbia University Medical Center, New York, NY 10032, USA 4.Department of Pediatrics,Columbia University Medical Center, New York, NY 10032, USA 5.Department of Neurology,Columbia University Medical Center, New York, NY 10032, USA 6.Fox Chase Cancer Center, Philadelphia, PA 19111, USA |
| 推荐引用方式 GB/T 7714 | Jones-Mason ME,Zhao XD,Kappes D,et al. E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells[J]. IMMUNITY,2012,36(3):348-361. |
| APA | Jones-Mason ME,Zhao XD,Kappes D,Lasorella A,Iavarone A,&Zhuang Y[*].(2012).E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells.IMMUNITY,36(3),348-361. |
| MLA | Jones-Mason ME,et al."E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells".IMMUNITY 36.3(2012):348-361. |
入库方式： OAI收割
来源：昆明动物研究所
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