Id proteins synchronize sternness and anchorage to the niche of neural stern cells
文献类型：期刊论文
| 作者 | Niola F1,8,9; Zhao XD1,8,9; Singh D1; Castano A1; Sullivan R1; Lauria M2,9; Nam HS3,9; Zhuang Y4; Benezra R3; Bernardo DD2 |
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 14期号:5页码:477-U80 |
| 通讯作者 | ai2102@columbia.edu or al2179@columbia.edu |
| 英文摘要 | Stem-cell functions require activation of stem-cell-intrinsic transcriptional programs and extracellular interaction with a niche microenvironment. How the transcriptional machinery controls residency of stem cells in the niche is unknown. Here we show that Id proteins coordinate stem-cell activities with anchorage of neural stem cells (NSCs) to the niche. Conditional inactivation of three Id genes in NSCs triggered detachment of embryonic and postnatal NSCs from the ventricular and vascular niche, respectively. The interrogation of the gene modules directly targeted by Id deletion in NSCs revealed that Id proteins repress bHLH-mediated activation of Rap1GAP, thus serving to maintain the GTPase activity of RAP1, a key mediator of cell adhesion. Preventing the elevation of the Rap1GAP level countered the consequences of Id loss on NSC niche interaction and stem-cell identity. Thus, by preserving anchorage of NSCs to the extracellular environment, Id activity synchronizes NSC functions to residency in the specialized niche. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento |
| 语种 | 英语 |
| 公开日期 | 2014-07-07 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7942]  |
| 专题 | 昆明动物研究所_科研共享资源 |
| 作者单位 | 1.Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA 2.Telethon Institute of Genetics and Medicine (TIGEM), Naples 80131, Italy 3.Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA 4.Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA 5.Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA. 6.Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA 7.Department of Pediatrics, Columbia University Medical Center, New York, New York 10032, USA 8.These authors contributed equally to this work. 9.Present addresses: Neuroscience and Brain Technologies, Fondazione Istituto Italiano di Tecnologia, Genoa 16163, Italy (F.N.); Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China (X.Z.); The Microsoft Research—University of Trento Centre for Computational and Systems Biology, I-38068 Rovereto (TN), Italy (M.L.); Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA (H-s.N.). |
| 推荐引用方式 GB/T 7714 | Niola F,Zhao XD,Singh D,et al. Id proteins synchronize sternness and anchorage to the niche of neural stern cells[J]. NATURE CELL BIOLOGY,2012,14(5):477-U80. |
| APA | Niola F.,Zhao XD.,Singh D.,Castano A.,Sullivan R.,...&Lasorella A[*].(2012).Id proteins synchronize sternness and anchorage to the niche of neural stern cells.NATURE CELL BIOLOGY,14(5),477-U80. |
| MLA | Niola F,et al."Id proteins synchronize sternness and anchorage to the niche of neural stern cells".NATURE CELL BIOLOGY 14.5(2012):477-U80. |
入库方式： OAI收割
来源：昆明动物研究所
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