The transcriptional network for mesenchymal transformation of brain tumours
文献类型：期刊论文
| 作者 | Carro MS[1]1; Lim WK[2,3]2,3; Alvarez MJ[3,4]3,4; Aldape K[12]12; Califano A[1,2,3,4]1,2,3,4; Iavarone A[1,5,7]1,5,7; Bollo RJ[8]8; Zhao XD[1]1; Snyder EY[9]9; Sulman EP[10]10 |
| 刊名 | NATURE
 |
| 出版日期 | 2010 |
| 卷号 | 463期号:7279页码:318-U68 |
| 通讯作者 | califano@c2b2.columbia.edu |
| 合作状况 | 其它 |
| 英文摘要 | The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma, but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBP beta and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBP beta and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage, whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma, expression of C/EBP beta and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2014-07-07 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7948]  |
| 专题 | 昆明动物研究所_科研共享资源 |
| 作者单位 | 1.Institute for Cancer Genetics,Columbia University Medical Center, New York, New York 10032, USA 2.Department of Biomedical Informatics,Columbia University Medical Center, New York, New York 10032, USA 3.Center for Computational Biology and Bioinformatics,Columbia University Medical Center, New York, New York 10032, USA 4.Joint Centers for Systems Biology,Columbia University Medical Center, New York, New York 10032, USA 5.Department of Pathology,Columbia University Medical Center, New York, New York 10032, USA 6.Department of Pediatrics,Columbia University Medical Center, New York, New York 10032, USA 7.Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA 8.Department of Neurosurgery, New York University School ofMedicine&NYULangone MedicalCenter,NewYork,NewYork10016,USA 9.Burnham Institute forMedicalResearch,LaJolla,California92037, USA 10.Division of Radiation Oncology,M.D. Anderson Cancer Center, Houston,Texas 77030,USA |
| 推荐引用方式 GB/T 7714 | Carro MS[1],Lim WK[2,3],Alvarez MJ[3,4],et al. The transcriptional network for mesenchymal transformation of brain tumours[J]. NATURE,2010,463(7279):318-U68. |
| APA | Carro MS[1].,Lim WK[2,3].,Alvarez MJ[3,4].,Aldape K[12].,Califano A[1,2,3,4].,...&Lasorella A[1,5,6].(2010).The transcriptional network for mesenchymal transformation of brain tumours.NATURE,463(7279),318-U68. |
| MLA | Carro MS[1],et al."The transcriptional network for mesenchymal transformation of brain tumours".NATURE 463.7279(2010):318-U68. |
入库方式： OAI收割
来源：昆明动物研究所
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