Stress-facilitated LTD induces output plasticity through a synchronized-spikes and spontaneous unitary discharges the CA1 region of the hippocampus
文献类型：期刊论文
| 作者 | Cao J1,2; Chen NH3; Xu TL4; Xu L[*]1,2 |
| 刊名 | NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2004 |
| 卷号 | 49期号:2页码:229-239 |
| 关键词 | long-term depression (LTD) long-term potentiation (LTP) spontaneous unitary discharges evoked synchronized spikes power spectrum stress |
| 通讯作者 | lxu@vip.163.com |
| 英文摘要 | Long-term potentiation (LTP) and long-term depression (LTD) of the excitatory synaptic inputs plasticity in the hippocampus is believed to underlie certain types of learning and memory. Especially, stressful experiences, well known to produce long-lasting strong memories of the event themselves, enable LTD by low frequency stimulation (LFS, 3 Hz) but block LTP induction by high frequency stimulation (HFS, 200 Hz). However, it is unknown whether stress-affected synaptic plasticity has an impact on the output plasticity. Thus, we have simultaneously studied the effects of stress on synaptic plasticity and neuronal output in the hippocampal CA1 region of anesthetized Wistar rats. Our results revealed that stress increased basal power spectrum of the evoked synchronized-spikes and enabled LTD induction by LFS. The induction of stress-facilitated LTD but not LFS induced persistent decreases of the power spectrum of the synchronized-spikes and the frequency of the spontaneous unitary discharges; However, HFS induced UP in non-stressed animals and increased the power spectrum of the synchronized-spikes, without affecting the frequency of the spontaneous unitary discharges, but HFS failed to induce UP in stressed animals without affecting the power spectrum of the synchronized-spikes and the frequency of the spontaneous unitary discharges. These observations that stress-facilitated LTD induces the output plasticity through the synchronized-spikes and spontaneous unitary discharges suggest that these types of stress-related plasticity may play significant roles in distribution, amplification and integration of encoded information to other brain structures under stressful conditions. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from The Chinese Academy of Sciences (KSCX2-SW-04) and The National Natural Science Foundation of China (39870280, 39925011, 39930080) and The National Basic Research Program (G1999054000) to L.X. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10898]  |
| 专题 | 昆明动物研究所_神经系统编码 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China 3.Center of Brain and Mind, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China 4.Laboratory of Synaptic Physiology, Institute of Neuroscience, The Chinese Academy of Sciences, Shanghai 200031, PR China |
| 推荐引用方式 GB/T 7714 | Cao J,Chen NH,Xu TL,et al. Stress-facilitated LTD induces output plasticity through a synchronized-spikes and spontaneous unitary discharges the CA1 region of the hippocampus[J]. NEUROSCIENCE RESEARCH,2004,49(2):229-239. |
| APA | Cao J,Chen NH,Xu TL,&Xu L[*].(2004).Stress-facilitated LTD induces output plasticity through a synchronized-spikes and spontaneous unitary discharges the CA1 region of the hippocampus.NEUROSCIENCE RESEARCH,49(2),229-239. |
| MLA | Cao J,et al."Stress-facilitated LTD induces output plasticity through a synchronized-spikes and spontaneous unitary discharges the CA1 region of the hippocampus".NEUROSCIENCE RESEARCH 49.2(2004):229-239. |
入库方式： OAI收割
来源：昆明动物研究所
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