Reduced startle habituation and prepulse inhibition in mice lacking the adenosine A(2A) receptor
文献类型：期刊论文
| 作者 | Wang JH1,2; Short J3; Ledent C4; Lawrence AJ3; van den Buuse M[*]1,5 |
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2003 |
| 卷号 | 143期号:2页码:201-207 |
| 关键词 | dopamine adenosine NMDA prepulse inhibition startle habituation knock-out mice |
| 通讯作者 | m.vandenbuuse@papyrus.mhri.edu.a |
| 英文摘要 | Adenosine and dopamine receptors interact in the CNS to modulate behaviour, including sensorimotor gating. Prepulse inhibition (PPI) has been suggested to be an operational measure of sensorimotor gating. PPI and startle habituation are disrupted in patients with schizophrenia. In experimental animals, both parameters are modulated by dopaminergic and adenosine receptor agonists and antagonists. In the present study, we measured PPI and startle habituation in mice that lack functional adenosine A(2A) receptors. Startle amplitudes, startle habituation and PPI were significantly reduced in mice homozygous null for the adenosine A(2A) receptor (A(2A)(-/-)). In addition, differential effects of amphetamine and MK-801 on startle amplitude, startle habituation and PPI were observed between A(2A)(-/-) and wildtype controls. These data support the involvement of adenosine A(2A) receptors in regulation of PPI and startle habituation. |
| 收录类别 | SCI |
| 资助信息 | This study was supported in part by grants from the Brockhoff Foundation, Parkinson Victoria and the National Health and Medical Research Council of Aus- tralia, Australia. Dr. M. van den Buuse is supported by a Griffith Senior Research Fellowship from the University of Melbourne, Australia. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10904]  |
| 专题 | 昆明动物研究所_神经系统编码 |
| 作者单位 | 1.Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak street, Parkville, Vic., Australia 2.Section of Cognitive Brain Research, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, PR China 3.Department of Pharmacology, Monash University, Clayton, Vic., Australia 4.IRIBHN, Faculty of Medicine, University of Brussels, Brussels, Belgium 5.Department of Pharmacology, University of Melbourne, Melbourne, Vic., Australia |
| 推荐引用方式 GB/T 7714 | Wang JH,Short J,Ledent C,et al. Reduced startle habituation and prepulse inhibition in mice lacking the adenosine A(2A) receptor[J]. BEHAVIOURAL BRAIN RESEARCH,2003,143(2):201-207. |
| APA | Wang JH,Short J,Ledent C,Lawrence AJ,&van den Buuse M[*].(2003).Reduced startle habituation and prepulse inhibition in mice lacking the adenosine A(2A) receptor.BEHAVIOURAL BRAIN RESEARCH,143(2),201-207. |
| MLA | Wang JH,et al."Reduced startle habituation and prepulse inhibition in mice lacking the adenosine A(2A) receptor".BEHAVIOURAL BRAIN RESEARCH 143.2(2003):201-207. |
入库方式： OAI收割
来源：昆明动物研究所
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