The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages
文献类型：期刊论文
| 作者 | Xiong WY1,2; Wei HN3; Wang YF1,2; Xu TL5; Xu L[*]1,2; Xiang XJ4; Cao J1,2; Dong ZF1,2 |
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2004 |
| 卷号 | 1005期号:1-2页码:187-192 |
| 关键词 | long-term potentiation long-term depression stress aberrant memory stress experience-dependent long-term depression (SLTD) |
| 通讯作者 | lxu@vip.163.com |
| 英文摘要 | Not all experiences are memorized equally well. Especially, some types of stress are unavoidable in daily life and the stress experience can be memorized for life. Previous evidence has showed that synaptic plasticity, such as long-term potentiation (LTP) that may be the major cellular model of the mechanism underlying learning and memory, is influenced by behavioral stress. However, the effect of behavioral stress on age-related synaptic plasticity in-vivo was primarily known. Here we found that the LTP induction in the hippocampal CA1 region of anesthetized rats obviously showed inverted-U shape related to ages (4, 10 and 74 weeks old rats), but low-frequency stimulation was unable to induce reliable long-term depression (LTD) in these animals. Furthermore, acute elevated platform (EP) stress enabled reliable LTD significantly and completely blocked LTP induction at these ages. Importantly, LTD after exposure to acute EP stress showed similar magnitude over these ages. The present results that stress enables LTD but impairs LTP induction at these three ages strengthen a view that stress experience-dependent LTD (SLTD) may underlie stress form of aberrant memories. |
| 收录类别 | SCI |
| 资助信息 | Basic Research Program G1999054000, National Natural Science grants 39870280, 39925011, 39930080 and Yunnan Science Foundation grant 98C111M of China to LX suppor- ted this work. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10899]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China 2.Graduate School of The Chinese Academy of Sciences, Beijing 100039, PR China 3.Kunming General Hospital, Chengdu Military Area, Kunming 650032, PR China 4.Mental Health Institute of Second Xiangya Hospital, Central-South University, Changsha 410011, PR China 5.Institute of Neuroscience, The Chinese Academy of Sciences, Shanghai 200031, PR China |
| 推荐引用方式 GB/T 7714 | Xiong WY,Wei HN,Wang YF,et al. The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages[J]. BRAIN RESEARCH,2004,1005(1-2):187-192. |
| APA | Xiong WY.,Wei HN.,Wang YF.,Xu TL.,Xu L[*].,...&Dong ZF.(2004).The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages.BRAIN RESEARCH,1005(1-2),187-192. |
| MLA | Xiong WY,et al."The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages".BRAIN RESEARCH 1005.1-2(2004):187-192. |
入库方式： OAI收割
来源：昆明动物研究所
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