Lead exposure through gestation-only caused long-term learning/memory deficits in young adult offspring
文献类型：期刊论文
| 作者 | Yang YX1; Ma YM[*]2; Zhang JY2; Fan M2; Liang CL3; Cao J1; Xu L[*]1; Ni LX2; Zhao SQ2; Li LJ2 |
| 刊名 | EXPERIMENTAL NEUROLOGY
 |
| 出版日期 | 2003 |
| 卷号 | 184期号:1页码:489-495 |
| 关键词 | hippocampus water maze spatial memory gestation lead offspring fetal exposure |
| 通讯作者 | lxu@vip.163.com |
| 英文摘要 | Numerous observations in clinical and preclinical studies indicate that the developing brain is particular sensitive to lead (Pb)'s pernicious effects. However, the effect of gestation-only Pb exposure on cognitive functions at maturation has not been studied. We investigated the potential effects of three levels of Pb exposure (low, middle, and high Pb: 0.03%, 0.09%, and 0.27% of lead acetate-containing diets) at the gestational period on the spatial memory of young adult offspring by Morris water maze spatial learning and fixed location/visible platform tasks. Our results revealed that three levels of Pb exposure significantly impaired memory retrieval in male offspring, but only female offspring at low levels of Pb exposure showed impairment of memory retrieval. These impairments were not due to the gross disturbances in motor performance and in vision because these animals performed the fixed location/visible platform task as well as controls, indicating that the specific aspects of spatial learning/memory were impaired. These results suggest that exposure to Pb during the gestational period is sufficient to cause long-term learning/memory deficits in young adult offspring. |
| 收录类别 | SCI |
| 资助信息 | We wish to thank The National Basic Research Program G1999054000, National Natural Science Grants 39870280, 39925011, 39930080, Yunnan Science Grant 98C111M and the Research Program of The Chinese Academy of Sciences of China to L.X., and the Kunming Institute of Zoology. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10901]  |
| 专题 | 昆明动物研究所_学习记忆的分子神经机制 |
| 作者单位 | 1.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China 2.Kunming Hospital of Children, Clinical Laboratory, Kunming 650034, Yunnan, PR China 3.Kunming General Hospital, Central Laboratory, Kunming, Yunnan, PR China |
| 推荐引用方式 GB/T 7714 | Yang YX,Ma YM[*],Zhang JY,et al. Lead exposure through gestation-only caused long-term learning/memory deficits in young adult offspring[J]. EXPERIMENTAL NEUROLOGY,2003,184(1):489-495. |
| APA | Yang YX.,Ma YM[*].,Zhang JY.,Fan M.,Liang CL.,...&Li LJ.(2003).Lead exposure through gestation-only caused long-term learning/memory deficits in young adult offspring.EXPERIMENTAL NEUROLOGY,184(1),489-495. |
| MLA | Yang YX,et al."Lead exposure through gestation-only caused long-term learning/memory deficits in young adult offspring".EXPERIMENTAL NEUROLOGY 184.1(2003):489-495. |
入库方式： OAI收割
来源：昆明动物研究所
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