Structural basis of nonribosomal peptide macrocyclization in fungi
文献类型：期刊论文
| 作者 | Zhang, Jinru1; Liu, Nicholas2; Cacho, Ralph A.2,7; Gong, Zhou3; Liu, Zhu4; Qin, Wenming5; Tang, Chun3,4; Tang, Yi2; Zhou, Jiahai1,6 |
| 刊名 | NATURE CHEMICAL BIOLOGY
 |
| 出版日期 | 2016-12-01 |
| 卷号 | 12期号:12页码:1001-+ |
| 英文摘要 | Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation-like (C-T) domain and the holo thiolation (T)-C-T complex of Penicillium aethiopicum TqaA. The first, to our knowledge, structural depiction of the terminal module in a fungal NRPS provides a molecular blueprint for generating new macrocyclic peptide natural products. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | MOLECULAR-MECHANISMS ; ASSEMBLY-LINE ; SYNTHETASE ; DOMAIN ; CONDENSATION ; ANTIBIOTICS ; CYCLIZATION ; CRYSTALLIZATION ; OPTIMIZATION ; SOFTWARE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000388582900006 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9978]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai, Peoples R China 2.Univ Calif Los Angeles, Dept Chem & Biochem, Dept Chem & Biomol Engn, 405 Hilgard Ave, Los Angeles, CA 90024 USA 3.Chinese Acad Sci, CAS Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom Mol Phys, Wuhan Inst Phys & Math, Wuhan, Peoples R China 4.Zhejiang Univ, Dept Pharmacol, Sch Med, Hangzhou, Zhejiang, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Natl Ctr Prot Sci Shanghai, Shanghai, Peoples R China 6.Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai, Peoples R China 7.Univ Washington, Dept Biochem, Inst Prot Design, Mol Engn & Sci, Seattle, WA 98195 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Jinru,Liu, Nicholas,Cacho, Ralph A.,et al. Structural basis of nonribosomal peptide macrocyclization in fungi[J]. NATURE CHEMICAL BIOLOGY,2016,12(12):1001-+. |
| APA | Zhang, Jinru.,Liu, Nicholas.,Cacho, Ralph A..,Gong, Zhou.,Liu, Zhu.,...&Zhou, Jiahai.(2016).Structural basis of nonribosomal peptide macrocyclization in fungi.NATURE CHEMICAL BIOLOGY,12(12),1001-+. |
| MLA | Zhang, Jinru,et al."Structural basis of nonribosomal peptide macrocyclization in fungi".NATURE CHEMICAL BIOLOGY 12.12(2016):1001-+. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。