Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei
文献类型：期刊论文
| 作者 | Yu, Yang1 ; Liu, Jingwen1,2; Li, Fuhua1,3; Zhang, Xiaojun1; Zhang, Chengsong1; Xiang, Jianhai1,3
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-01-17 |
| 卷号 | 7 |
| 英文摘要 | White Spot Syndrome Virus (WSSV) is regarded as a virus with the strongest pathogenicity to shrimp. For the threshold trait such as disease resistance, marker assisted selection (MAS) was considered to be a more effective approach. In the present study, association analyses of single nucleotide polymorphisms (SNPs) located in a set of immune related genes were conducted to identify markers associated with WSSV resistance. SNPs were detected by bioinformatics analysis on RNA sequencing data generated by Illimina sequencing platform and Roche 454 sequencing technology. A total of 681 SNPs located in the exons of immune related genes were selected as candidate SNPs. Among these SNPs, 77 loci were genotyped in WSSV susceptible group and resistant group. Association analysis was performed based on logistic regression method under an additive and dominance model in GenABEL package. As a result, five SNPs showed associations with WSSV resistance at a significant level of 0.05. Besides, SNP-SNP interaction analysis was conducted. The combination of SNP loci in TRAF6, Cu/Zn SOD and nLvALF2 exhibited a significant effect on the WSSV resistance of shrimp. Gene expression analysis revealed that these SNPs might influence the expression of these immune-related genes. This study provides a useful method for performing MAS in shrimp. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000391939100001 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/136289]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Yang,Liu, Jingwen,Li, Fuhua,et al. Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Yu, Yang,Liu, Jingwen,Li, Fuhua,Zhang, Xiaojun,Zhang, Chengsong,&Xiang, Jianhai.(2017).Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei.SCIENTIFIC REPORTS,7. |
| MLA | Yu, Yang,et al."Gene set based association analyses for the WSSV resistance of Pacific white shrimp Litopenaeus vannamei".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：海洋研究所
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