The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas
文献类型：期刊论文
| 作者 | Liu, Zhaoqun1,3 ; Zhou, Zhi1; Jiang, Qiufen1; Wang, Lingling2; Yi, Qilin2; Qiu, Limei1; Song, Linsheng2
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| 刊名 | OPEN BIOLOGY
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| 出版日期 | 2017 |
| 卷号 | 7期号:1 |
| 关键词 | Crassostrea gigas neuroendocrine immunomodulatory axis circulating haemocyte membrane receptor immune regulation |
| 英文摘要 | The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocyteswas characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the 'nervous-haemocyte' NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000393382200012 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/136335]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Dalian Ocean Univ, Minist Agr, Key Lab Mariculture & Stock Enhancement North Chi, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhaoqun,Zhou, Zhi,Jiang, Qiufen,et al. The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas[J]. OPEN BIOLOGY,2017,7(1). |
| APA | Liu, Zhaoqun.,Zhou, Zhi.,Jiang, Qiufen.,Wang, Lingling.,Yi, Qilin.,...&Song, Linsheng.(2017).The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas.OPEN BIOLOGY,7(1). |
| MLA | Liu, Zhaoqun,et al."The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas".OPEN BIOLOGY 7.1(2017). |
入库方式： OAI收割
来源：海洋研究所
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