Tracing mesenchymal stem cells in treated uterine horns trauma of rats with magnetic resonance imaging
文献类型：期刊论文
| 作者 | Zhou, B; Li, XA; Ding, LJ; Wang, JM; Zang, FC; Cao, Y; Wang, QB(王强斌); Deng, ZW(邓宗武); Dai, JW; Hu, YL |
| 刊名 | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
 |
| 出版日期 | 2016 |
| 卷号 | 9期号:2 |
| 通讯作者 | Hu, YL ; Deng, ZW(邓宗武) ; Dai, JW |
| 英文摘要 | Stem cells have shown a great promise to treat uterine injury. However, long-term and noninvasive tracking of stem cells in uterine horns is still challenging. In the present study, high-field magnetic resonance imaging (MRI) was applied in the tracking mesenchymal stem cells derived from human umbilical cord blood (UCB-MSCs) in reparation of uterine horns trauma of rats. Nano-sized MR contrast agent SPIO@SiO2 (silica nanoparticle coated super-paramagnetic iron oxide nanoparticle) labeled UCB-MSCs. We found that SPIO@SiO2 labeled UCB-MSCs could be detected in the surgical region in vivo 7 days postoperatively using 7.0 T MRI. By 30 days, the labeled cells only could be detected using 11.7 T MRI in vivo. SPIO@SiO2 labeled UCB-MSCs were mainly in the myometrium and serosal junction area. MRI findings were highly correlated to Prussian blue staining results. Our findings indicate that high-field MRI monitoring of the early phase of this model may provide unique opportunities to study stem cells implantation. |
| 关键词[WOS] | ASHERMANS-SYNDROME ; IN-VITRO ; TRACKING ; MRI ; NANOPARTICLES ; BRAIN |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374655200033 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/4535]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队 |
| 推荐引用方式 GB/T 7714 | Zhou, B,Li, XA,Ding, LJ,et al. Tracing mesenchymal stem cells in treated uterine horns trauma of rats with magnetic resonance imaging[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2016,9(2). |
| APA | Zhou, B.,Li, XA.,Ding, LJ.,Wang, JM.,Zang, FC.,...&Hu, YL.(2016).Tracing mesenchymal stem cells in treated uterine horns trauma of rats with magnetic resonance imaging.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9(2). |
| MLA | Zhou, B,et al."Tracing mesenchymal stem cells in treated uterine horns trauma of rats with magnetic resonance imaging".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9.2(2016). |
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