Improving the solubility of dexlansoprazole by cocrystallization with isonicotinamide
文献类型：期刊论文
| 作者 | Li, JH; Wang, LY; Ye, YQ; Fu, X; Ren, QH; Zhang, HL(张海禄); Deng, ZW(邓宗武) |
| 刊名 | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
 |
| 出版日期 | 2016 |
| 卷号 | 85 |
| 通讯作者 | Zhang, HL(张海禄) |
| 英文摘要 | Cocrystallization of an active pharmaceutical ingredient (API) with a cocrystal former (co-former) is widely used to tailor the physicochemical properties of parent APIs. For proton-pump inhibitors (PPIs), the isolation of cocrystals has not been widely investigated. Here, a 1:1 cocrystal of a PPI molecule, dexlansoprazole (DLS), was obtained by solvent crystallization with isonicotinamide (INM). The product was characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), solid-state and liquid NMR, as well as Fourier transform infrared spectroscopy (FTIR) techniques. A two-point R-2(2) (9) hetero-synthon was proposed to exist in the cocrystal, where intermolecular hydrogen bonding occurs between NH, SO groups of DLS and amide of INM. The dissolution profiles of DLS and DLS-INM in water were also collected, and the results demonstrate the cocrystal exhibits superior apparent maximum solubility relative to the pure drug. (C) 2016 Elsevier B.V. All rights reserved. |
| 关键词[WOS] | PHARMACEUTICAL COCRYSTALS ; SOLID-STATE ; ORAL BIOAVAILABILITY ; CRYSTAL ; LANSOPRAZOLE ; FORMS ; STABILITY ; DRUGS ; ACIDS ; OMEPRAZOLE |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000371996000006 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/4809]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队 |
| 推荐引用方式 GB/T 7714 | Li, JH,Wang, LY,Ye, YQ,et al. Improving the solubility of dexlansoprazole by cocrystallization with isonicotinamide[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2016,85. |
| APA | Li, JH.,Wang, LY.,Ye, YQ.,Fu, X.,Ren, QH.,...&Deng, ZW.(2016).Improving the solubility of dexlansoprazole by cocrystallization with isonicotinamide.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,85. |
| MLA | Li, JH,et al."Improving the solubility of dexlansoprazole by cocrystallization with isonicotinamide".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 85(2016). |
入库方式： OAI收割
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