Characterization and toxicological effects of three-dimensional graphene foams in rats in vivo
文献类型：期刊论文
| 作者 | Zha, YY; Chai, RJ; Song, Q(宋琴); Chen, L; Wang, XX; Cheng, GS(程国胜); Tang, ML; Wang, M |
| 刊名 | JOURNAL OF NANOPARTICLE RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 18期号:5 |
| 通讯作者 | Wang, M ; Tang, ML |
| 英文摘要 | Current studies have demonstrated the advantage of graphene-based materials, which suggests their potential usage for biomedical applications. However, the in vivo toxicity and performance of three-dimensional (3D) graphene foams (GFs) remain largely unclear. In the present study, we identified the short-term and long-term tissue responses to GFs or graphene oxide foams (GOFs) in a rat model of subcutaneous implantation. Results from blood biochemistry, hematological analysis, histological examination, and behavioral test all indicated nearly no noticeable in vivo toxicity in either GF-or GOF-implanted rats during the first 2 weeks post-implantation. In addition, hematoxylin and eosin (H and E) stained images showed GFs or GOFs remained in the subcutaneous implantation site for at least 7 months without significant degradation after implantation. Our study demonstrates the non-biodegradable feature of GFs and GOFs as implanted scaffolds, while they exhibit good biocompatibility in vivo. It adds new evidence for the in vivo toxicological study of GFs and GOFs, which may provide reference for their biomedical applications. |
| 关键词[WOS] | FOREIGN-BODY RESPONSE ; BIOMEDICAL APPLICATIONS ; SUBCUTANEOUS IMPLANTS ; FAMILY NANOMATERIALS ; STEM-CELLS ; OXIDE ; BIOCOMPATIBILITY ; INTERFACE ; MICE ; NANOCOMPOSITES |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375791200003 |
| 源URL | [http://ir.sinano.ac.cn/handle/332007/4568]  |
| 专题 | 苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_程国胜团队 |
| 推荐引用方式 GB/T 7714 | Zha, YY,Chai, RJ,Song, Q,et al. Characterization and toxicological effects of three-dimensional graphene foams in rats in vivo[J]. JOURNAL OF NANOPARTICLE RESEARCH,2016,18(5). |
| APA | Zha, YY.,Chai, RJ.,Song, Q.,Chen, L.,Wang, XX.,...&Wang, M.(2016).Characterization and toxicological effects of three-dimensional graphene foams in rats in vivo.JOURNAL OF NANOPARTICLE RESEARCH,18(5). |
| MLA | Zha, YY,et al."Characterization and toxicological effects of three-dimensional graphene foams in rats in vivo".JOURNAL OF NANOPARTICLE RESEARCH 18.5(2016). |
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